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    Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tab3provided by RGD
    Official Full Name
    TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by RGD
    Primary source
    RGD:1594527
    See related
    EnsemblRapid:ENSRNOG00000003643 AllianceGenome:RGD:1594527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in defense response to bacterium; non-canonical NF-kappaB signal transduction; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in endoplasmic reticulum. Orthologous to human TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 46.6), Kidney (RPKM 38.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tab3 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (53923473..53995777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (49972414..50044658)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (54035958..54090282)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ferritin, heavy polypeptide-like 17, member A Neighboring gene xanthine dehydrogenase, pseudogene 1 Neighboring gene glycerol kinase Neighboring gene replication protein A 14 kDa subunit pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-Regulation of TAB3 Is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage. Zhu L, et al. Cell Mol Neurobiol, 2017 May. PMID 27352012
    2. miR-23b/TAB3/NF-κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid. Roshan-Milani S, et al. Biofactors, 2022 Jul. PMID 35201648
    3. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. Brown J, et al. J Dent Res, 2011 Apr. PMID 20940366, Free PMC Article
    4. Tripartite motif 38 attenuates cardiac fibrosis after myocardial infarction by suppressing TAK1 activation via TAB2/3 degradation. Lu Z, et al. iScience, 2022 Aug 19. PMID 35982795, Free PMC Article
    5. Expanding role of ubiquitination in NF-κB signaling. Liu S, et al. Cell Res, 2011 Jan. PMID 21135871, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-23b/TAB3/NF-kappaB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid.
      Title: miR-23b/TAB3/NF-κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia-reperfusion in rats: The protective effect of chlorogenic acid.
    2. TAB3 level was accompanied by the increased expression of active-caspase-3, active-caspase-8, and decreased expression of Bcl-2
      Title: Up-Regulation of TAB3 Is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta activated kinase 1 (MAP3K7) binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Names
    TGF-beta activated kinase 1 and MAP3K7 binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433003.1 → NP_001419932.1  TGF-beta activated kinase 1 (MAP3K7) binding protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IPW0, F1M1D2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      53923473..53995777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100565.2 → XP_038956493.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

      Related
      ENSRNOP00000004854.8, ENSRNOT00000004854.9
      Conserved Domains (3) summary
      smart00547
      Location:690 → 712
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:690 → 709
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. XM_039100567.2 → XP_038956495.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      A6IPW0, F1M1D2
      Conserved Domains (3) summary
      smart00547
      Location:690 → 712
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:690 → 709
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    3. XM_039100564.1 → XP_038956492.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABN5, A6IPW0
      Related
      ENSRNOP00000089411.1, ENSRNOT00000100917.2
      Conserved Domains (3) summary
      smart00547
      Location:700 → 722
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:700 → 719
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl21463
      Location:37 → 60
      UBA_like_SF; UBA domain-like superfamily

    RNA

    1. XR_005498528.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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