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    Shd src homology 2 domain-containing transforming protein D [ Mus musculus (house mouse) ]

    Gene ID: 20420, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shdprovided by MGI
    Official Full Name
    src homology 2 domain-containing transforming protein Dprovided by MGI
    Primary source
    MGI:MGI:1099461
    See related
    Ensembl:ENSMUSG00000039154 AllianceGenome:MGI:1099461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Orthologous to human SHD (Src homology 2 domain containing transforming protein D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 43.7), CNS E14 (RPKM 40.5) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Shd in Genome Data Viewer
    Location:
    17 D; 17 29.09 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56276828..56283624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55969828..55976620)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 119b Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene predicted gene, 16712 Neighboring gene Epstein-Barr virus induced gene 3 Neighboring gene YJU2 splicing factor Neighboring gene fibronectin type 3 and SPRY domain-containing protein Neighboring gene signal transducing adaptor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2497

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC118480

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    SH2 domain-containing adapter protein D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159523.2NP_001152995.1  SH2 domain-containing adapter protein D isoform 1

      See identical proteins and their annotated locations for NP_001152995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154235, CT009719
      Consensus CDS
      CCDS50149.1
      UniProtKB/Swiss-Prot
      O88834
      Related
      ENSMUSP00000153605.2, ENSMUST00000223629.2
      Conserved Domains (1) summary
      cd10390
      Location:224321
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)
    2. NM_001410665.1NP_001397594.1  SH2 domain-containing adapter protein D isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    3. NM_001410666.1NP_001397595.1  SH2 domain-containing adapter protein D isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    4. NM_001410667.1NP_001397596.1  SH2 domain-containing adapter protein D isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    5. NM_001410668.1NP_001397597.1  SH2 domain-containing adapter protein D isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    6. NM_001410669.1NP_001397598.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    7. NM_001410670.1NP_001397599.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    8. NM_001410671.1NP_001397600.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    9. NM_001410672.1NP_001397601.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    10. NM_001410673.1NP_001397602.1  SH2 domain-containing adapter protein D isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719
    11. NM_009168.3NP_033194.1  SH2 domain-containing adapter protein D isoform 2

      See identical proteins and their annotated locations for NP_033194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC154235, CT009719
      Consensus CDS
      CCDS89120.1
      UniProtKB/Swiss-Prot
      O88834, Q3SYI7
      Related
      ENSMUSP00000047656.8, ENSMUST00000044216.8
      Conserved Domains (1) summary
      cd10390
      Location:223320
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

    RNA

    1. NR_177106.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154235, CT009719

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56276828..56283624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249612.1XP_030105472.1  SH2 domain-containing adapter protein D isoform X2

      UniProtKB/Swiss-Prot
      O88834, Q3SYI7
      Conserved Domains (1) summary
      cd10390
      Location:223320
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)
    2. XM_011246334.4XP_011244636.1  SH2 domain-containing adapter protein D isoform X1

      See identical proteins and their annotated locations for XP_011244636.1

      UniProtKB/Swiss-Prot
      O88834
      Conserved Domains (1) summary
      cd10390
      Location:224321
      SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)