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    Sgo1 shugoshin 1 [ Mus musculus (house mouse) ]

    Gene ID: 72415, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgo1provided by MGI
    Official Full Name
    shugoshin 1provided by MGI
    Primary source
    MGI:MGI:1919665
    See related
    Ensembl:ENSMUSG00000023940 AllianceGenome:MGI:1919665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sgol1; 3300001M08Rik
    Summary
    Predicted to enable kinase binding activity. Acts upstream of or within centriole-centriole cohesion. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 10.7), CNS E11.5 (RPKM 8.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sgo1 in Genome Data Viewer
    Location:
    17 C; 17 27.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (53981814..53996432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (53674786..53691331, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42833 Neighboring gene STARR-seq mESC enhancer starr_42835 Neighboring gene STARR-seq mESC enhancer starr_42837 Neighboring gene K(lysine) acetyltransferase 2B Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42842 Neighboring gene STARR-seq mESC enhancer starr_42845 Neighboring gene STARR-positive B cell enhancer ABC_E8685 Neighboring gene predicted gene, 31532 Neighboring gene RAB5A, member RAS oncogene family, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC113769

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in attachment of spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within centriole-centriole cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centriole-centriole cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within meiotic chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in mitotic sister chromatid cohesion, centromeric IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic sister chromatid cohesion, centromeric ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    shugoshin 1
    Names
    shugoshin 1A protein
    shugoshin-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028232.2NP_082508.1  shugoshin 1

      See identical proteins and their annotated locations for NP_082508.1

      Status: VALIDATED

      Source sequence(s)
      AK014357, AK049517, BY394301, CR522550
      Consensus CDS
      CCDS28881.1
      UniProtKB/Swiss-Prot
      Q3U4K4, Q588H1, Q8BKW2, Q9CXH7
      Related
      ENSMUSP00000024736.8, ENSMUST00000024736.14
      Conserved Domains (2) summary
      pfam07557
      Location:465486
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:2266
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      53981814..53996432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246642.4XP_011244944.1  shugoshin 1 isoform X1

      See identical proteins and their annotated locations for XP_011244944.1

      UniProtKB/Swiss-Prot
      Q3U4K4, Q588H1, Q8BKW2, Q9CXH7
      Conserved Domains (2) summary
      pfam07557
      Location:465486
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:2266
      Shugoshin_N; Shugoshin N-terminal coiled-coil region