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    Kat2b K(lysine) acetyltransferase 2B [ Mus musculus (house mouse) ]

    Gene ID: 18519, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kat2bprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 2Bprovided by MGI
    Primary source
    MGI:MGI:1343094
    See related
    Ensembl:ENSMUSG00000000708 AllianceGenome:MGI:1343094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcaf; p/CAF; A930006P13Rik
    Summary
    Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in several processes, including internal peptidyl-lysine acetylation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within positive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 12.8), bladder adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kat2b in Genome Data Viewer
    Location:
    17 C; 17 27.86 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (53873802..53979749)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (53566774..53672721)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42830 Neighboring gene tumor protein, translationally-controlled, pseudogene 7 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42833 Neighboring gene STARR-seq mESC enhancer starr_42835 Neighboring gene STARR-seq mESC enhancer starr_42837 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42842 Neighboring gene STARR-seq mESC enhancer starr_42845 Neighboring gene STARR-positive B cell enhancer ABC_E8685 Neighboring gene shugoshin 1 Neighboring gene predicted gene, 31532

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diamine N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables histone H3K9 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K9 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to parathyroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of gluconeogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within internal peptidyl-lysine acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in internal peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in limb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gluconeogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein acetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in I band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in actomyosin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT2B
    Names
    histone acetylase PCAF
    histone acetyltransferase PCAF
    lysine acetyltransferase 2B
    p300/CBP-associated factor
    spermidine acetyltransferase KAT2B
    NP_001177775.1
    NP_064389.2
    XP_006523883.1
    XP_036016288.1
    XP_036016289.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190846.1NP_001177775.1  histone acetyltransferase KAT2B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC140263, AK030070
      Conserved Domains (4) summary
      cd05509
      Location:630729
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:390729
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:453525
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:8229
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    2. NM_020005.5NP_064389.2  histone acetyltransferase KAT2B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131785, AC140263
      Consensus CDS
      CCDS28880.1
      UniProtKB/Swiss-Prot
      Q3U142, Q640M9, Q9JHD1
      UniProtKB/TrEMBL
      B2RR30
      Related
      ENSMUSP00000000724.9, ENSMUST00000000724.15
      Conserved Domains (4) summary
      cd05509
      Location:708807
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:468807
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:531603
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:56307
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RNA

    1. NR_151733.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131785, AC140263

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      53873802..53979749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523820.5XP_006523883.1  histone acetyltransferase KAT2B isoform X1

      Conserved Domains (3) summary
      cd05509
      Location:569668
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:329668
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:1168
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    2. XM_036160396.1XP_036016289.1  histone acetyltransferase KAT2B isoform X3

      Conserved Domains (2) summary
      COG5076
      Location:329440
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:1168
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    3. XM_036160395.1XP_036016288.1  histone acetyltransferase KAT2B isoform X2

      Conserved Domains (2) summary
      COG5076
      Location:468579
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:56307
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RNA

    1. XR_001782056.3 RNA Sequence