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    Dlg4 discs large MAGUK scaffold protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 13385, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dlg4provided by MGI
    Official Full Name
    discs large MAGUK scaffold protein 4provided by MGI
    Primary source
    MGI:MGI:1277959
    See related
    Ensembl:ENSMUSG00000020886 AllianceGenome:MGI:1277959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlgh4; PSD95; SAP90; PSD-95; SAP90A
    Summary
    Enables ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein localization to synapse; regulation of long-term neuronal synaptic plasticity; and synaptic vesicle maturation. Located in several cellular components, including axon; postsynaptic density; and synaptic vesicle. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Colocalizes with postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 161.9), frontal lobe adult (RPKM 143.5) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dlg4 in Genome Data Viewer
    Location:
    11 B3; 11 42.96 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69908029..69938107)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70017203..70045535)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-Coenzyme A dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene STARR-positive B cell enhancer ABC_E11483 Neighboring gene STARR-positive B cell enhancer ABC_E1421 Neighboring gene STARR-positive B cell enhancer ABC_E2358 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene predicted gene, 32946

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (15)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D1 dopamine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables P2Y1 nucleotide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables P2Y1 nucleotide receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables beta-1 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-1 adrenergic receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables beta-2 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurexin family protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables neuroligin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuroligin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in AMPA glutamate receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in AMPA glutamate receptor clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in NMDA selective glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to potassium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendritic spine morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic spine organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in locomotory behavior NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic neurotransmitter receptor diffusion trapping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein localization to synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor localization to synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuronal synaptic plasticity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to cocaine NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic vesicle maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within synaptic vesicle maturation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vocalization behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cerebellar mossy fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic branch ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    disks large homolog 4
    Names
    PSD-95 alpha 2b
    PSD-95 beta
    SAP-90
    discs large homolog 4
    discs, large homolog 4
    postsynaptic density protein 95
    synapse-associated protein 90

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109752.1NP_001103222.1  disks large homolog 4 isoform 2

      See identical proteins and their annotated locations for NP_001103222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 6. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 6.
      Source sequence(s)
      BC014807, BQ959940, CA320223
      Consensus CDS
      CCDS48829.1
      UniProtKB/TrEMBL
      G3UZL5
      Related
      ENSMUSP00000156345.2, ENSMUST00000231415.2
      Conserved Domains (7) summary
      cd12030
      Location:427492
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:541707
      GuKc; Guanylate kinase homologues
      smart00228
      Location:307391
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:62146
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:530708
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:242309
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1061
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. NM_001370671.1NP_001357600.1  disks large homolog 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596185
      UniProtKB/TrEMBL
      G3UZL5
      Conserved Domains (6) summary
      cd12030
      Location:435500
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:315399
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00625
      Location:538716
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:250317
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam00595
      Location:70154
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam10608
      Location:1969
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    3. NM_001370672.1NP_001357601.1  disks large homolog 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596185
      Consensus CDS
      CCDS88179.1
      UniProtKB/TrEMBL
      A0A338P6E5, G3UZL5
      Conserved Domains (5) summary
      cd12030
      Location:370435
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:250334
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:589
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:473651
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:185252
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    4. NM_001370674.1NP_001357603.1  disks large homolog 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596185
      UniProtKB/TrEMBL
      G3UZL5
      Conserved Domains (6) summary
      cd12030
      Location:406471
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:286370
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00625
      Location:509687
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:221288
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam00595
      Location:41125
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam10608
      Location:1040
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    5. NM_001370675.1NP_001357604.1  disks large homolog 4 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (6)
      Source sequence(s)
      AL596185
      Consensus CDS
      CCDS88178.1
      UniProtKB/TrEMBL
      A0A338P6I6, G3UZL5
      Related
      ENSMUSP00000155973.2, ENSMUST00000231506.2
      Conserved Domains (7) summary
      cd12030
      Location:470535
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:350434
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00625
      Location:573751
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:285352
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam00595
      Location:105189
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam10608
      Location:54104
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cl02672
      Location:2647
      L27; L27 domain
    6. NM_001430918.1NP_001417847.1  disks large homolog 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL596185
      UniProtKB/TrEMBL
      G3UZL5
    7. NM_007864.3NP_031890.1  disks large homolog 4 isoform 1

      See identical proteins and their annotated locations for NP_031890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 6. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 6.
      Source sequence(s)
      BC014807, BI738861, BQ959940, CA320223
      Consensus CDS
      CCDS36202.1
      UniProtKB/Swiss-Prot
      Q5NCV5, Q5NCV6, Q5NCV7, Q62108, Q91WJ1
      UniProtKB/TrEMBL
      G3UZL5
      Related
      ENSMUSP00000104229.3, ENSMUST00000108588.9
      Conserved Domains (7) summary
      cd12030
      Location:430495
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00072
      Location:544710
      GuKc; Guanylate kinase homologues
      smart00228
      Location:310394
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:65149
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:533711
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:245312
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1064
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69908029..69938107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156285.1XP_036012178.1  disks large homolog 4 isoform X1

      UniProtKB/TrEMBL
      G3UZL5
      Conserved Domains (6) summary
      cd12030
      Location:463528
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:343427
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:98182
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:566744
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278345
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1097
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    2. XM_006532144.3XP_006532207.1  disks large homolog 4 isoform X2

      See identical proteins and their annotated locations for XP_006532207.1

      UniProtKB/TrEMBL
      G3UZL5
      Conserved Domains (6) summary
      cd12030
      Location:460525
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:340424
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:95179
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:563741
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:275342
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1094
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    3. XM_006532148.3XP_006532211.1  disks large homolog 4 isoform X4

      See identical proteins and their annotated locations for XP_006532211.1

      UniProtKB/TrEMBL
      G3UZL5
      Conserved Domains (6) summary
      cd12030
      Location:408473
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:288372
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:43127
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:511689
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:223290
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1142
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    4. XM_006532150.3XP_006532213.1  disks large homolog 4 isoform X5

      Conserved Domains (6) summary
      cd12030
      Location:405470
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:285369
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:40124
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:508686
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:220287
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:1139
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    5. XM_036156286.1XP_036012179.1  disks large homolog 4 isoform X6

      UniProtKB/TrEMBL
      A0A338P6E5, G3UZL5
      Related
      ENSMUSP00000018700.8, ENSMUST00000018700.14
      Conserved Domains (5) summary
      cd12030
      Location:370435
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:250334
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      pfam00595
      Location:589
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00625
      Location:473651
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:185252
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    6. XM_006532147.5XP_006532210.3  disks large homolog 4 isoform X3

      UniProtKB/TrEMBL
      G3UZL5
      Conserved Domains (6) summary
      cd12030
      Location:409474
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      smart00228
      Location:289373
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:44127
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:512690
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:224291
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:843
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RNA

    1. XR_001779872.2 RNA Sequence