Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp3ccprovided by MGI
Official Full Name: protein phosphatase 3, catalytic subunit, gamma isoformprovided by MGI
Primary source: MGI:MGI:107162
See related: Ensembl:ENSMUSG00000022092 AllianceGenome:MGI:107162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Calnc; PP2BA gamma
Summary: Enables calcium-dependent protein serine/threonine phosphatase activity. Acts upstream of or within penetration of zona pellucida. Located in mitochondrion and sperm mitochondrial sheath. Part of calcineurin complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in gastrocnemius muscle; ovary; renal vasculature; and upper jaw molar. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 21.7), frontal lobe adult (RPKM 6.2) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.3 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70455314..70526979, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70217864..70289536, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer.
Title: A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance.
this stusy demonstrates that male mice lacking Ppp3cc or Ppp3r2 genes (knockout mice) are infertile, with reduced sperm motility owing to an inflexible midpiece.
Title: Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M81475 (e-PCR)
- UniSTS:124988

M81475 (e-PCR)
- UniSTS:160409

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcineurin-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium ion import across plasma membrane	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within penetration of zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	IDA Inferred from Direct Assay more info	PubMed
part_of calcineurin complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of calcineurin complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of protein serine/threonine phosphatase complex	NAS Non-traceable Author Statement more info	PubMed
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm mitochondrial sheath	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Names: CAM-PRP catalytic subunit; calcineurin, testis-specific catalytic subunit

NP_001291920.1

EC 3.1.3.16

NP_001291921.1

EC 3.1.3.16

NP_001347158.1

EC 3.1.3.16

NP_001411449.1

EC 3.1.3.16

NP_032941.1

EC 3.1.3.16

XP_017171413.1

EC 3.1.3.16

XP_030103550.1

EC 3.1.3.16

XP_030103551.1

EC 3.1.3.16

XP_036014406.1

EC 3.1.3.16

XP_036014407.1

EC 3.1.3.16

XP_036014408.1

EC 3.1.3.16

XP_036014409.1

EC 3.1.3.16

XP_036014410.1

EC 3.1.3.16

XP_036014411.1

EC 3.1.3.16

XP_036014412.1

EC 3.1.3.16

XP_036014413.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304991.2 → NP_001291920.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC139294, AC151836

Consensus CDS

CCDS88703.1

UniProtKB/TrEMBL

A0A2I3BPC5, Q80XK0

Related

ENSMUSP00000153725.2, ENSMUST00000228911.2

Conserved Domains (2) summary

smart00156
Location:54 → 325

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07416
Location:37 → 341

MPP_PP2B; PP2B, metallophosphatase domain
NM_001304992.2 → NP_001291921.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate exons and uses a downstream start codon compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AC139294, AC151836

UniProtKB/TrEMBL

Q80XK0

Conserved Domains (1) summary

cl13995
Location:1 → 173

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
NM_001360229.2 → NP_001347158.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 4

Status: VALIDATED

Source sequence(s)

AC139294, AC151836

UniProtKB/TrEMBL

Q9D5R5

Related

ENSMUST00000228265.2

Conserved Domains (1) summary

cd07416
Location:37 → 341

MPP_PP2B; PP2B, metallophosphatase domain
NM_001424520.1 → NP_001411449.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 5

Status: VALIDATED

Source sequence(s)

AC139294, AC151836
NM_008915.4 → NP_032941.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

See identical proteins and their annotated locations for NP_032941.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC139294, AC151836

Consensus CDS

CCDS36968.1

UniProtKB/Swiss-Prot

P48455, Q3V074

UniProtKB/TrEMBL

Q80XK0

Related

ENSMUSP00000077532.7, ENSMUST00000078434.8

Conserved Domains (2) summary

smart00156
Location:54 → 325

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07416
Location:37 → 341

MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70455314..70526979 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158519.1 → XP_036014412.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

Conserved Domains (1) summary

cl13995
Location:14 → 146

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_036158518.1 → XP_036014411.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

Conserved Domains (1) summary

cl13995
Location:14 → 146

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_030247691.2 → XP_030103551.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X8

Conserved Domains (1) summary

cl13995
Location:14 → 146

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_036158516.1 → XP_036014409.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

Conserved Domains (1) summary

cl13995
Location:1 → 173

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_036158517.1 → XP_036014410.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

Conserved Domains (1) summary

cl13995
Location:1 → 173

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_017315924.3 → XP_017171413.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X8

Conserved Domains (1) summary

cl13995
Location:14 → 146

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_030247690.2 → XP_030103550.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6

Conserved Domains (1) summary

cl13995
Location:1 → 173

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_036158515.1 → XP_036014408.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4

UniProtKB/TrEMBL

Q80XK0

Conserved Domains (1) summary

cd07416
Location:37 → 341

MPP_PP2B; PP2B, metallophosphatase domain
XM_036158513.1 → XP_036014406.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

UniProtKB/TrEMBL

Q80XK0

Conserved Domains (1) summary

cd07416
Location:37 → 341

MPP_PP2B; PP2B, metallophosphatase domain
XM_036158520.1 → XP_036014413.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X9

Conserved Domains (1) summary

cl13995
Location:14 → 146

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_036158514.1 → XP_036014407.1 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3

UniProtKB/TrEMBL

Q9D5R5

Conserved Domains (1) summary

cd07416
Location:37 → 341

MPP_PP2B; PP2B, metallophosphatase domain