Htatip2 HIV-1 Tat interactive protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htatip2provided by MGI
Official Full Name: HIV-1 Tat interactive protein 2provided by MGI
Primary source: MGI:MGI:1859271
See related: Ensembl:ENSMUSG00000039745 AllianceGenome:MGI:1859271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cc3; Tip30
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in import into nucleus and regulation of angiogenesis. Predicted to act upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Predicted to be located in cytosol and nuclear envelope. Predicted to be active in cytoplasm. Is expressed in heart and limb. Orthologous to human HTATIP2 (HIV-1 Tat interactive protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 15.4), placenta adult (RPKM 12.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 31.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (49408761..49423748)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (49759045..49774000)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigating TIP30-Mediated regulation of mTORC1 signaling as a therapeutic strategy for coxsackievirus B3-Induced viral myocarditis.
Title: Investigating TIP30-Mediated regulation of mTORC1 signaling as a therapeutic strategy for coxsackievirus B3-Induced viral myocarditis.
Overexpression or knockdown of Htatip2 in hepatocytes affected fatty acid storage and oxidation, consistent with a novel role in mediating the differential effects of PKC isoforms on lipid metabolism.
Title: Proteomic analysis of livers from fat-fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism.
Data suggest that TIP30 plays a negative regulatory role in oligodendroglial differentiation.
Title: TIP30 inhibits oligodendrocyte precursor cell differentiation via cytoplasmic sequestration of Olig1.
TIP30 is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage, and loss of it promotes expansion of ER(+) luminal progenitors and mature cells and ER(+) mammary tumorigenesis.
Title: Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.
TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung.
Title: TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice.
TIP30 complex regulates EGFR endocytosis by facilitating the transport of V-ATPases from trans-Golgi network to early endosomes.
Title: A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation.
Results suggest that Tip30 is an intrinsic and negative regulator of MEC proliferation partly through the inhibition of Wisp2 and Igf-1 expression, and its absence in the mammary gland may predispose MECs to neoplastic transformation.
Title: Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF061972 (e-PCR)
- UniSTS:163419

AW111545 (e-PCR)
- UniSTS:179579

NoName (e-PCR)
- UniSTS:235674

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in import into nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: oxidoreductase HTATIP2

Names: HIV-1 tat interactive protein 2, 30 kDa homolog; HIV-1 tat interactive protein 2, homolog; tat-interacting protein 30 kDa

NP_001139521.1

EC 1.1.1.-

NP_001139522.1

EC 1.1.1.-

NP_001139524.1

EC 1.1.1.-

NP_001139525.1

EC 1.1.1.-

NP_058561.2

EC 1.1.1.-

XP_006541052.1

EC 1.1.1.-

XP_030098630.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146049.1 → NP_001139521.1 oxidoreductase HTATIP2 isoform b

See identical proteins and their annotated locations for NP_001139521.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.

Source sequence(s)

AK144837, AW121187, BY292123

Consensus CDS

CCDS52260.1

UniProtKB/Swiss-Prot

Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9

Related

ENSMUSP00000082374.6, ENSMUST00000085272.7

Conserved Domains (1) summary

cd05250
Location:19 → 231

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
NM_001146050.1 → NP_001139522.1 oxidoreductase HTATIP2 isoform b

See identical proteins and their annotated locations for NP_001139522.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.

Source sequence(s)

AK151254, AW121187, BB575839, CB593552

Consensus CDS

CCDS52260.1

UniProtKB/Swiss-Prot

Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9

Conserved Domains (1) summary

cd05250
Location:19 → 231

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
NM_001146052.1 → NP_001139524.1 oxidoreductase HTATIP2 isoform b

See identical proteins and their annotated locations for NP_001139524.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.

Source sequence(s)

AK008630, AK151254, AW121187, CB318388

Consensus CDS

CCDS52260.1

UniProtKB/Swiss-Prot

Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9

Conserved Domains (1) summary

cd05250
Location:19 → 231

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
NM_001146053.1 → NP_001139525.1 oxidoreductase HTATIP2 isoform b

See identical proteins and their annotated locations for NP_001139525.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.

Source sequence(s)

AK151254, AW121187, BB575839

Consensus CDS

CCDS52260.1

UniProtKB/Swiss-Prot

Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9

Conserved Domains (1) summary

cd05250
Location:19 → 231

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
NM_016865.3 → NP_058561.2 oxidoreductase HTATIP2 isoform a

See identical proteins and their annotated locations for NP_058561.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AK151254, AW121187, BY292123

Consensus CDS

CCDS85310.1

UniProtKB/TrEMBL

Q3U816

Related

ENSMUSP00000146858.2, ENSMUST00000207895.2

Conserved Domains (2) summary

cd05250
Location:52 → 264

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs

COG0702
Location:54 → 226

YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

49408761..49423748

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242770.2 → XP_030098630.1 oxidoreductase HTATIP2 isoform X2

Conserved Domains (1) summary

cd05250
Location:19 → 219

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
XM_006540989.1 → XP_006541052.1 oxidoreductase HTATIP2 isoform X1

Conserved Domains (1) summary

cd05250
Location:52 → 252

CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs