Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf14provided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)provided by MGI
Primary source: MGI:MGI:2675303
See related: Ensembl:ENSMUSG00000042333 AllianceGenome:MGI:2675303
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TR2; Atar; HveA; Hvem; Tnfrs14
Summary: Predicted to enable cytokine binding activity and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including defense response to bacterium; negative regulation of CD4-positive, alpha-beta T cell proliferation; and positive regulation of macromolecule metabolic process. Located in external side of plasma membrane. Is expressed in liver lobe. Orthologous to human TNFRSF14 (TNF receptor superfamily member 14). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in liver E14.5 (RPKM 52.1), spleen adult (RPKM 43.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 85.81 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155002944..155013077, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (154918487..154928620, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The BTLA-HVEM axis restricts CAR T cell efficacy in cancer.
Title: The BTLA-HVEM axis restricts CAR T cell efficacy in cancer.
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1[-] stem cell-like T cells over PD-1[+] T cells curbing tumor progression.
Title: Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1(-) stem cell-like T cells over PD-1(+) T cells curbing tumor progression.
Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development.
Title: Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development.
LIGHT Amplification by NF-kappaB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis.
Title: LIGHT Amplification by NF-κB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis.
The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
Title: The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses.
Title: HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses.
HVEM Promotes the Osteogenesis of allo-MSCs by Inhibiting the Secretion of IL-17 and IFN-gamma in Vgamma4T Cells.
Title: HVEM Promotes the Osteogenesis of allo-MSCs by Inhibiting the Secretion of IL-17 and IFN-γ in Vγ4T Cells.
Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection.
Title: Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection.
these results establish that HVEM restrains the T helper signals delivered to B cells to influence germinal center selection outcomes
Title: The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
The HVEM ligand CD160 counterbalances stimulatory signals in highly activated and cytotoxic CD8(+) T effector cells.
Title: HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of adaptive immune memory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of alpha-beta T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 14

Names: herpes virus entry mediator A; herpesvirus entry mediator A; tumor necrosis factor receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178931.2 → NP_849262.1 tumor necrosis factor receptor superfamily member 14 precursor

Status: PROVISIONAL

Source sequence(s)

AY264405

Consensus CDS

CCDS19017.1

UniProtKB/Swiss-Prot

Q80WM9

UniProtKB/TrEMBL

Q3SXX1

Related

ENSMUSP00000116757.2, ENSMUST00000123514.8

Conserved Domains (3) summary

cd00185
Location:138 → 201

TNFRSF; CRD2 [structural motif]

cd10582
Location:42 → 142

TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)

cl22855
Location:99 → 229

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

155002944..155013077 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538832.4 → XP_006538895.1 tumor necrosis factor receptor superfamily member 14 isoform X3

Conserved Domains (1) summary

cd10582
Location:42 → 135

TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
XM_006538831.4 → XP_006538894.1 tumor necrosis factor receptor superfamily member 14 isoform X2

UniProtKB/Swiss-Prot

Q80WM9

UniProtKB/TrEMBL

Q3SXX1

Conserved Domains (3) summary

cd00185
Location:138 → 201

TNFRSF; CRD2 [structural motif]

cd10582
Location:42 → 142

TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)

cl22855
Location:99 → 229

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_006538830.2 → XP_006538893.1 tumor necrosis factor receptor superfamily member 14 isoform X1

UniProtKB/TrEMBL

A0A1W2P7D5, Q71F55

Conserved Domains (3) summary

cd00185
Location:99 → 135

TNFRSF; CRD1 [structural motif]

cd10582
Location:42 → 142

TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)

cl22855
Location:99 → 229

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_011250244.2 → XP_011248546.1 tumor necrosis factor receptor superfamily member 14 isoform X1

UniProtKB/TrEMBL

A0A1W2P7D5, Q71F55

Related

ENSMUSP00000151575.2, ENSMUST00000219534.3

Conserved Domains (3) summary

cd00185
Location:99 → 135

TNFRSF; CRD1 [structural motif]

cd10582
Location:42 → 142

TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)

cl22855
Location:99 → 229

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_006538833.3 → XP_006538896.1 tumor necrosis factor receptor superfamily member 14 isoform X4

UniProtKB/TrEMBL

Q8VC17

Conserved Domains (2) summary

cd00185
Location:89 → 148

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

cd10582
Location:1 → 87

TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)
XM_030253512.1 → XP_030109372.1 tumor necrosis factor receptor superfamily member 14 isoform X5

Conserved Domains (1) summary

cd10582
Location:42 → 142

TNFRSF14; Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM)