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    Ebi3 Epstein-Barr virus induced gene 3 [ Mus musculus (house mouse) ]

    Gene ID: 50498, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ebi3provided by MGI
    Official Full Name
    Epstein-Barr virus induced gene 3provided by MGI
    Primary source
    MGI:MGI:1354171
    See related
    Ensembl:ENSMUSG00000003206 AllianceGenome:MGI:1354171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EBI-3; IL-27
    Summary
    Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 18.1), mammary gland adult (RPKM 10.2) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ebi3 in Genome Data Viewer
    Location:
    17 D; 17 29.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56259623..56264022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55952623..55957022)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_42873 Neighboring gene STARR-positive B cell enhancer ABC_E4220 Neighboring gene zinc finger protein 119b Neighboring gene STARR-positive B cell enhancer ABC_E7546 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene predicted gene, 16712 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-27 receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-27 subunit beta
    Names
    IL-27 subunit beta
    IL-27B
    epstein-Barr virus-induced gene 3 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015766.2NP_056581.1  interleukin-27 subunit beta precursor

      See identical proteins and their annotated locations for NP_056581.1

      Status: VALIDATED

      Source sequence(s)
      AW495532, BI134394, BY134465, CX240802
      Consensus CDS
      CCDS28888.1
      UniProtKB/Swiss-Prot
      O35228
      UniProtKB/TrEMBL
      Q3U1K3
      Related
      ENSMUSP00000003274.7, ENSMUST00000003274.8
      Conserved Domains (1) summary
      cd00063
      Location:128216
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56259623..56264022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524599.5XP_006524662.1  interleukin-27 subunit beta isoform X1

      Conserved Domains (1) summary
      cd00063
      Location:27115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...