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    Trip12 thyroid hormone receptor interactor 12 [ Mus musculus (house mouse) ]

    Gene ID: 14897, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trip12provided by MGI
    Official Full Name
    thyroid hormone receptor interactor 12provided by MGI
    Primary source
    MGI:MGI:1309481
    See related
    Ensembl:ENSMUSG00000026219 AllianceGenome:MGI:1309481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gtl6; TRIP-12; 1110036I07Rik; 6720416K24Rik
    Summary
    Predicted to enable nuclear thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Involved in regulation of embryonic development. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in several structures, including brain and genitourinary system. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 27.8), placenta adult (RPKM 25.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trip12 in Genome Data Viewer
    Location:
    1 C5; 1 43.42 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (84698910..84818285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (84721189..84850004, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene delta/notch-like EGF repeat containing Neighboring gene STARR-seq mESC enhancer starr_01515 Neighboring gene predicted gene, 57795 Neighboring gene microRNA 5126 Neighboring gene predicted gene, 51637 Neighboring gene STARR-seq mESC enhancer starr_01519 Neighboring gene STARR-seq mESC enhancer starr_01525 Neighboring gene F-box protein 36 Neighboring gene STARR-seq mESC enhancer starr_01531 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 14 Neighboring gene predicted gene, 39669 Neighboring gene predicted pseudogene 15433

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC31615

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterochromatin boundary formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterochromatin boundary formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIP12
    Names
    HECT-type E3 ubiquitin transferase TRIP12
    TR-interacting protein 12
    gene trap locus 6
    thyroid receptor interactor TRIP12
    thyroid receptor-interacting protein 12
    NP_598736.4
    XP_006496472.1
    XP_006496477.1
    XP_006496479.1
    XP_006496485.1
    XP_006496490.1
    XP_006496492.1
    XP_011236956.1
    XP_011236957.1
    XP_011236959.1
    XP_011236960.1
    XP_011236961.1
    XP_011236963.1
    XP_011236964.1
    XP_011236965.1
    XP_011236966.1
    XP_011236968.1
    XP_011236969.1
    XP_011236970.1
    XP_011236971.1
    XP_011236972.1
    XP_011236975.1
    XP_017172116.1
    XP_017172162.1
    XP_030104755.1
    XP_030104782.1
    XP_030104802.1
    XP_030104858.1
    XP_030104872.1
    XP_030104920.1
    XP_030105028.1
    XP_030105040.1
    XP_030105055.1
    XP_030105107.1
    XP_030105119.1
    XP_030105145.1
    XP_030105170.1
    XP_030105185.1
    XP_036016722.1
    XP_036016773.1
    XP_036016798.1
    XP_036016802.1
    XP_036016854.1
    XP_036016870.1
    XP_036016899.1
    XP_036017009.1
    XP_036017145.1
    XP_036017160.1
    XP_036017182.1
    XP_036017235.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133975.4NP_598736.4  E3 ubiquitin-protein ligase TRIP12

      See identical proteins and their annotated locations for NP_598736.4

      Status: VALIDATED

      Source sequence(s)
      AC123882, AK158807, AW543112, BG695625, CA319321, CF747879, CN536706, DV647354
      Consensus CDS
      CCDS35633.1
      UniProtKB/Swiss-Prot
      G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
      UniProtKB/TrEMBL
      A0A087WNZ7
      Related
      ENSMUSP00000027421.7, ENSMUST00000027421.13
      Conserved Domains (3) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16232023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769830
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      84698910..84818285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238658.4XP_011236960.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236960.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16722072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814876
      WWE; WWE domain
    2. XM_011238673.4XP_011236975.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16272027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767832
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    3. XM_036160961.1XP_036016854.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16442044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:786848
      WWE; WWE domain
    4. XM_011238669.4XP_011236971.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      See identical proteins and their annotated locations for XP_011236971.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16302030
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:770835
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    5. XM_011238655.4XP_011236957.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236957.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16722072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814876
      WWE; WWE domain
    6. XM_030249180.2XP_030105040.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16272027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767832
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    7. XM_030249310.2XP_030105170.1  E3 ubiquitin-protein ligase TRIP12 isoform X30

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:418643
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:15981998
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:738803
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    8. XM_030249285.2XP_030105145.1  E3 ubiquitin-protein ligase TRIP12 isoform X29

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:418643
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16012001
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:741806
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    9. XM_030249325.2XP_030105185.1  E3 ubiquitin-protein ligase TRIP12 isoform X33

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:15911991
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767804
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    10. XM_006496429.3XP_006496492.1  E3 ubiquitin-protein ligase TRIP12 isoform X31

      UniProtKB/TrEMBL
      A0A087WNZ7
      Related
      ENSMUSP00000139563.2, ENSMUST00000186648.7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:15961996
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767804
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    11. XM_006496427.4XP_006496490.1  E3 ubiquitin-protein ligase TRIP12 isoform X25

      See identical proteins and their annotated locations for XP_006496490.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16262026
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767831
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    12. XM_030249168.2XP_030105028.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16272027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767832
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    13. XM_011238668.4XP_011236970.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      See identical proteins and their annotated locations for XP_011236970.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16302030
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:770835
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    14. XM_036160829.1XP_036016722.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16722072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814876
      WWE; WWE domain
    15. XM_006496416.5XP_006496479.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16652065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:811872
      WWE; WWE domain
    16. XM_030249247.2XP_030105107.1  E3 ubiquitin-protein ligase TRIP12 isoform X27

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16182018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769830
      WWE; WWE domain
    17. XM_036161342.1XP_036017235.1  E3 ubiquitin-protein ligase TRIP12 isoform X32

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:418643
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:15941994
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:740801
      WWE; WWE domain
    18. XM_030248998.2XP_030104858.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16412041
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809846
      WWE; WWE domain
    19. XM_006496414.5XP_006496477.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16682068
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809873
      WWE; WWE domain
    20. XM_030248922.2XP_030104782.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16612061
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809874
      WWE; WWE domain
    21. XM_030248895.2XP_030104755.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16662066
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809874
      WWE; WWE domain
    22. XM_006496409.5XP_006496472.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16692069
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809874
      WWE; WWE domain
    23. XM_011238666.4XP_011236968.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16442044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812849
      WWE; WWE domain
    24. XM_036160909.1XP_036016802.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16632063
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814875
      WWE; WWE domain
    25. XM_036160880.1XP_036016773.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16682068
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814875
      WWE; WWE domain
    26. XM_011238661.4XP_011236963.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16712071
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812876
      WWE; WWE domain
    27. XM_011238664.4XP_011236966.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16642064
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812877
      WWE; WWE domain
    28. XM_011238663.4XP_011236965.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16672067
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812877
      WWE; WWE domain
    29. XM_011238662.4XP_011236964.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16692069
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:812877
      WWE; WWE domain
    30. XM_011238654.4XP_011236956.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236956.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16722072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814876
      WWE; WWE domain
    31. XM_006496422.5XP_006496485.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16382038
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809846
      WWE; WWE domain
    32. XM_030248942.2XP_030104802.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16602060
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809873
      WWE; WWE domain
    33. XM_030249012.2XP_030104872.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16392039
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:809847
      WWE; WWE domain
    34. XM_036161267.1XP_036017160.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

      UniProtKB/Swiss-Prot
      G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16232023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769830
      WWE; WWE domain
    35. XM_030249259.2XP_030105119.1  E3 ubiquitin-protein ligase TRIP12 isoform X28

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:432657
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16112011
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:752816
      WWE; WWE domain
    36. XM_030249060.2XP_030104920.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16312031
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:780844
      WWE; WWE domain
    37. XM_036161116.1XP_036017009.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16362036
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:782843
      WWE; WWE domain
    38. XM_011238667.4XP_011236969.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16432043
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:785847
      WWE; WWE domain
    39. XM_017316673.3XP_017172162.1  E3 ubiquitin-protein ligase TRIP12 isoform X20

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16372037
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:781845
      WWE; WWE domain
    40. XM_017316627.3XP_017172116.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16442044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:786848
      WWE; WWE domain
    41. XM_011238659.3XP_011236961.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236961.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16722072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814876
      WWE; WWE domain
    42. XM_036160977.1XP_036016870.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:461686
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16442044
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:786848
      WWE; WWE domain
    43. XM_036161006.1XP_036016899.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:460685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16432043
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:785847
      WWE; WWE domain
    44. XM_011238657.4XP_011236959.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_011236959.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16722072
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:814876
      WWE; WWE domain
    45. XM_011238670.4XP_011236972.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

      See identical proteins and their annotated locations for XP_011236972.1

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16302030
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:770835
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    46. XM_030249195.2XP_030105055.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (4) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16272027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767832
      WWE; WWE domain
      pfam07263
      Location:12165
      DMP1; Dentin matrix protein 1 (DMP1)
    47. XM_036161252.1XP_036017145.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

      UniProtKB/Swiss-Prot
      G5E870, Q3TY88, Q3UYT5, Q8BM59, Q8K051
      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16232023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769830
      WWE; WWE domain
    48. XM_036160905.1XP_036016798.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:489714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16652065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:811872
      WWE; WWE domain
    49. XM_036161289.1XP_036017182.1  E3 ubiquitin-protein ligase TRIP12 isoform X27

      UniProtKB/TrEMBL
      A0A087WNZ7
      Conserved Domains (3) summary
      COG5064
      Location:447672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:16182018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769830
      WWE; WWE domain