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    Htr2b 5-hydroxytryptamine (serotonin) receptor 2B [ Mus musculus (house mouse) ]

    Gene ID: 15559, updated on 27-Nov-2024

    Summary

    Official Symbol
    Htr2bprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 2Bprovided by MGI
    Primary source
    MGI:MGI:109323
    See related
    Ensembl:ENSMUSG00000026228 AllianceGenome:MGI:109323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5-HT2B; 5-HT-2B; 5-HT-2F
    Summary
    Enables G protein-coupled serotonin receptor activity; GTPase activator activity; and serotonin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; phospholipase C-activating serotonin receptor signaling pathway; and positive regulation of endothelial cell proliferation. Acts upstream of or within heart development. Located in cytoplasm and plasma membrane. Part of G protein-coupled serotonin receptor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Htr2b in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86025268..86043960, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86097546..86116231, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810459M11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1552 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Neighboring gene predicted gene, 22786 Neighboring gene predicted gene, 53570 Neighboring gene STARR-seq mESC enhancer starr_01562 Neighboring gene STARR-seq mESC enhancer starr_01563 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:88051083-88051236 Neighboring gene STARR-positive B cell enhancer ABC_E4330 Neighboring gene armadillo repeat containing 9 Neighboring gene STARR-seq mESC enhancer starr_01567 Neighboring gene STARR-positive B cell enhancer mm9_chr1:88110756-88111056 Neighboring gene STARR-positive B cell enhancer mm9_chr1:88125353-88125654 Neighboring gene STARR-seq mESC enhancer starr_01568 Neighboring gene STARR-positive B cell enhancer mm9_chr1:88154834-88155134 Neighboring gene predicted gene, 46098 Neighboring gene predicted gene 16341

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables Gq/11-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Gq/11-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serotonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serotonin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled serotonin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to amine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to serotonin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intestine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestine smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating serotonin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating serotonin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within phospholipase C-activating serotonin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of G protein-coupled serotonin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of G protein-coupled serotonin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 2B
    Names
    NP75 protein
    serotonin receptor 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008311.3NP_032337.2  5-hydroxytryptamine receptor 2B

      Status: VALIDATED

      Source sequence(s)
      AC157768
      Consensus CDS
      CCDS35644.1
      UniProtKB/Swiss-Prot
      Q02152, Q8JZK5, Q9QWS2
      Related
      ENSMUSP00000027431.7, ENSMUST00000027431.7
      Conserved Domains (2) summary
      pfam00001
      Location:70379
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:70161
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      86025268..86043960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529146.4XP_006529209.1  5-hydroxytryptamine receptor 2B isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:5581
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:54413
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_030250037.1XP_030105897.1  5-hydroxytryptamine receptor 2B isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:88117
      7tm_GPCRs; TM helix 5 [structural motif]
      cl28897
      Location:59272
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily