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    ZNF580 zinc finger protein 580 [ Homo sapiens (human) ]

    Gene ID: 51157, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF580provided by HGNC
    Official Full Name
    zinc finger protein 580provided by HGNC
    Primary source
    HGNC:HGNC:29473
    See related
    Ensembl:ENSG00000213015 MIM:617888; AllianceGenome:HGNC:29473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cell migration; and positive regulation of interleukin-8 production. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 10.9), prostate (RPKM 9.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF580 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55641002..55643470)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58736919..58739384)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56152368..56154836)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56135913-56136412 Neighboring gene zinc finger protein 784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15100 Neighboring gene uncharacterized LOC107983998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15101 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:56146823-56146990 Neighboring gene zinc finger protein 581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11051 Neighboring gene Sharpr-MPRA regulatory region 1979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56155949-56156914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15105 Neighboring gene coiled-coil domain containing 106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15107 Neighboring gene U2 small nuclear RNA auxiliary factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    zinc finger protein 580
    Names
    LDL-induced EC protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163423.2NP_001156895.1  zinc finger protein 580

      See identical proteins and their annotated locations for NP_001156895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC008735, AF184939, BM793208
      Consensus CDS
      CCDS12931.1
      UniProtKB/Swiss-Prot
      B2RC05, Q9NPP7, Q9UK33
      Related
      ENSP00000446126.1, ENST00000545125.1
      Conserved Domains (2) summary
      sd00017
      Location:94114
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:120142
      zf-C2H2; Zinc finger, C2H2 type
    2. NM_016202.2NP_057286.1  zinc finger protein 580

      See identical proteins and their annotated locations for NP_057286.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AF184939, BM700178, BM710177, BQ477323
      Consensus CDS
      CCDS12931.1
      UniProtKB/Swiss-Prot
      B2RC05, Q9NPP7, Q9UK33
      Related
      ENSP00000443957.1, ENST00000543039.2
      Conserved Domains (2) summary
      sd00017
      Location:94114
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:120142
      zf-C2H2; Zinc finger, C2H2 type
    3. NM_207115.2NP_996998.1  zinc finger protein 580

      See identical proteins and their annotated locations for NP_996998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC008735, AF184939, AL359054, BU179609
      Consensus CDS
      CCDS12931.1
      UniProtKB/Swiss-Prot
      B2RC05, Q9NPP7, Q9UK33
      Related
      ENSP00000320050.4, ENST00000325333.10
      Conserved Domains (2) summary
      sd00017
      Location:94114
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:120142
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55641002..55643470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58736919..58739384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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