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    Il5ra interleukin 5 receptor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 16192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il5raprovided by MGI
    Official Full Name
    interleukin 5 receptor, alphaprovided by MGI
    Primary source
    MGI:MGI:96558
    See related
    Ensembl:ENSMUSG00000005364 AllianceGenome:MGI:96558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il5r; CD125; CDw125
    Summary
    Predicted to enable cytokine binding activity and interleukin-5 receptor activity. Acts upstream of or within inflammatory response to antigenic stimulus and regulation of interleukin-5 production. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5RA (interleukin 5 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Il5ra in Genome Data Viewer
    Location:
    6 E1; 6 49.19 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (106687336..106725998, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (106710375..106749037, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16930 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene predicted gene 15631 Neighboring gene contactin 4 Neighboring gene STARR-seq mESC enhancer starr_16931 Neighboring gene STARR-seq mESC enhancer starr_16932 Neighboring gene STARR-seq mESC enhancer starr_16934 Neighboring gene STARR-seq mESC enhancer starr_16935 Neighboring gene STARR-seq mESC enhancer starr_16936 Neighboring gene STARR-positive B cell enhancer ABC_E6462 Neighboring gene STARR-positive B cell enhancer ABC_E4850 Neighboring gene STARR-positive B cell enhancer ABC_E9278 Neighboring gene STARR-seq mESC enhancer starr_16937 Neighboring gene STARR-positive B cell enhancer ABC_E3665 Neighboring gene tRNA nucleotidyl transferase, CCA-adding, 1 Neighboring gene cereblon Neighboring gene predicted gene, 34873

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the murine IL-5 receptor complex with the use of a panel of monoclonal antibodies. Relationship to the murine IL-3 receptor. Van der Heyden J, et al. J Immunol, 1991 Nov 15. PMID 1940345
    2. Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition. Ishino T, et al. J Biol Chem, 2004 Mar 5. PMID 14662768
    3. [Structure and function of IL-5 receptor]. Takatsu K. Yakugaku Zasshi, 1995 Aug. PMID 7473055
    4. Molecular cloning and expression of the murine interleukin-5 receptor. Takaki S, et al. EMBO J, 1990 Dec. PMID 2265612, Free PMC Article
    5. Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells. Itakura A, et al. Int Arch Allergy Immunol, 2006. PMID 16772721

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. More than neutrophils: Lin(+)Ly6G(+)IL-5Ralpha(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes.
      Title: More than neutrophils: Lin(+)Ly6G(+)IL-5Rα(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes.
    2. Expression of IL-5 receptor alpha by murine and human lung neutrophils.
      Title: Expression of IL-5 receptor alpha by murine and human lung neutrophils.
    3. SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells.
      Title: SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Rα-dependent mechanism in B-1 cells.
    4. Deglycosylated variant Il5ralpha has the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn196 glycosylation in IL5Ralpha function.
      Title: A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor α.
    5. We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver
      Title: Expression of IL-5Ralpha on B-1 cell progenitors in mouse fetal liver and involvement of Bruton's tyrosine kinase in their development.
    6. Octamer Transcription Factor 2 (Oct2) augments the ability of activated B cells to differentiate to antibody-secreting plasma cells under T cell-dependent conditions through regulation of the gene encoding the interleukin 5 receptor alpha chain.
      Title: Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells.
    7. Interleukin-5 receptor alpha chain expression and splicing during brain development in mice.
      Title: Interleukin-5 receptor alpha chain expression and splicing during brain development in mice.
    8. IL-5 is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 gene-deleted mice
      Title: Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo.
    9. The murine interleukin-5 receptor alpha chain pre-mRNA is alternatively spliced, resulting in soluble isoforms lacking the transmembrane coding region which do not complex with the IL-5R beta chain.
      Title: Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-5 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-5 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interleukin-5-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-5-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of interleukin-5 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-5 receptor subunit alpha
    Names
    IL-5 receptor alpha chain
    IL-5 receptor subunit alpha
    IL-5R subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008370.2 → NP_032396.1  interleukin-5 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_032396.1

      Status: VALIDATED

      Source sequence(s)
      AC164169
      Consensus CDS
      CCDS20396.1
      UniProtKB/Swiss-Prot
      P21183
      UniProtKB/TrEMBL
      Q05A81
      Related
      ENSMUSP00000144718.2, ENSMUST00000204659.3
      Conserved Domains (2) summary
      cd00063
      Location:237 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:128 → 233
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      106687336..106725998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321406.1 → XP_017176895.1  interleukin-5 receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      P21183
      UniProtKB/TrEMBL
      Q05A81
      Conserved Domains (2) summary
      cd00063
      Location:237 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:128 → 233
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21183.1 GenPept UniProtKB/Swiss-Prot:P21183

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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