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    Cbfa2t2 CBFA2/RUNX1 translocation partner 2 [ Mus musculus (house mouse) ]

    Gene ID: 12396, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cbfa2t2provided by MGI
    Official Full Name
    CBFA2/RUNX1 translocation partner 2provided by MGI
    Primary source
    MGI:MGI:1333833
    See related
    Ensembl:ENSMUSG00000038533 AllianceGenome:MGI:1333833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTGR1; Cbfa2t2h; A430091M07; C330013D05Rik
    Summary
    Enables transcription corepressor activity. Involved in intestinal epithelial cell differentiation and negative regulation of Notch signaling pathway. Acts upstream of or within epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and sensory organ. Orthologous to human CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 10.6), CNS E14 (RPKM 10.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cbfa2t2 in Genome Data Viewer
    Location:
    2 H1; 2 76.62 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154278018..154381276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154436098..154539356)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06119 Neighboring gene VISTA enhancer mm1461 Neighboring gene predicted gene, 39962 Neighboring gene STARR-seq mESC enhancer starr_06124 Neighboring gene predicted gene, 52564 Neighboring gene STARR-seq mESC enhancer starr_06127 Neighboring gene zinc finger, FYVE domain containing 21 pseudogene Neighboring gene RIKEN cDNA 1700003F12 gene Neighboring gene N-terminal EF-hand calcium binding protein 3 Neighboring gene actin-like 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein CBFA2T2
    Names
    CBFA2T2 identified gene homolog
    MTG8-like protein
    MTG8-related protein 1
    core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285446.1NP_001272375.1  protein CBFA2T2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL772292
      Conserved Domains (3) summary
      pfam01753
      Location:281317
      zf-MYND; MYND finger
      pfam08788
      Location:105171
      NHR2; NHR2 domain like
      cl27055
      Location:212280
      MutS_III; MutS domain III
    2. NM_009823.1NP_033953.1  protein CBFA2T2 isoform 2

      See identical proteins and their annotated locations for NP_033953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AK040403, AK148027, BC064679
      Consensus CDS
      CCDS50764.1
      UniProtKB/TrEMBL
      A0A0R4J1D5
      Related
      ENSMUSP00000105347.2, ENSMUST00000109725.8
      Conserved Domains (4) summary
      pfam01753
      Location:497533
      zf-MYND; MYND finger
      pfam07531
      Location:106192
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:322388
      NHR2; NHR2 domain like
      cl27055
      Location:433496
      MutS_III; MutS domain III
    3. NM_172860.2NP_766448.1  protein CBFA2T2 isoform 1

      See identical proteins and their annotated locations for NP_766448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AK148027, BC064679
      Consensus CDS
      CCDS16932.1
      UniProtKB/Swiss-Prot
      B2RRH8, O70374, Q30BK8, Q6P288
      Related
      ENSMUSP00000043087.9, ENSMUST00000045270.15
      Conserved Domains (4) summary
      pfam01753
      Location:498534
      zf-MYND; MYND finger
      pfam07531
      Location:106192
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:322388
      NHR2; NHR2 domain like
      cl27055
      Location:429497
      MutS_III; MutS domain III

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      154278018..154381276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157841.1XP_036013734.1  protein CBFA2T2 isoform X6

      UniProtKB/TrEMBL
      F6WYU8
      Related
      ENSMUSP00000118371.2, ENSMUST00000137526.2
      Conserved Domains (3) summary
      PRK00409
      Location:161229
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam08788
      Location:54120
      NHR2; NHR2 domain like
      pfam01753
      Location:230266
      zf-MYND; MYND finger
    2. XM_006498642.3XP_006498705.1  protein CBFA2T2 isoform X4

      Conserved Domains (4) summary
      PRK00409
      Location:255323
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam01753
      Location:324360
      zf-MYND; MYND finger
      pfam07531
      Location:106191
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:171214
      NHR2; NHR2 domain like
    3. XM_036157840.1XP_036013733.1  protein CBFA2T2 isoform X5

      Conserved Domains (4) summary
      PRK00409
      Location:259322
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam08788
      Location:171214
      NHR2; NHR2 domain like
      pfam01753
      Location:323359
      zf-MYND; MYND finger
      pfam07531
      Location:106191
      TAFH; NHR1 homology to TAF
    4. XM_006498641.2XP_006498704.1  protein CBFA2T2 isoform X2

      Conserved Domains (4) summary
      PRK00409
      Location:381449
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam01753
      Location:450486
      zf-MYND; MYND finger
      pfam07531
      Location:58147
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:274340
      NHR2; NHR2 domain like
    5. XM_030247023.1XP_030102883.1  protein CBFA2T2 isoform X3

      Conserved Domains (4) summary
      PRK00409
      Location:385448
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam01753
      Location:449485
      zf-MYND; MYND finger
      pfam07531
      Location:58147
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:274340
      NHR2; NHR2 domain like
    6. XM_006498640.4XP_006498703.1  protein CBFA2T2 isoform X1

      See identical proteins and their annotated locations for XP_006498703.1

      UniProtKB/Swiss-Prot
      O70374
      Conserved Domains (4) summary
      PRK00409
      Location:409477
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam01753
      Location:478514
      zf-MYND; MYND finger
      pfam07531
      Location:86175
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:302368
      NHR2; NHR2 domain like