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    Lrg1 leucine-rich alpha-2-glycoprotein 1 [ Mus musculus (house mouse) ]

    Gene ID: 76905, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrg1provided by MGI
    Official Full Name
    leucine-rich alpha-2-glycoprotein 1provided by MGI
    Primary source
    MGI:MGI:1924155
    See related
    Ensembl:ENSMUSG00000037095 AllianceGenome:MGI:1924155
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrg; Lrhg; 1300008B03Rik; 2310031E04Rik
    Summary
    Enables transforming growth factor beta receptor binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of endothelial cell proliferation; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in pancreas mesenchyme. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 229.9), mammary gland adult (RPKM 136.7) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrg1 in Genome Data Viewer
    Location:
    17 29.17 cM; 17 D
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56426678..56428946, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56119678..56121946, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene STARR-positive B cell enhancer ABC_E5621 Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E7547 Neighboring gene myeloid derived growth factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC102387

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type II transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    leucine-rich alpha-2-glycoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029796.2NP_084072.1  leucine-rich alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_084072.1

      Status: PROVISIONAL

      Source sequence(s)
      BC030733
      Consensus CDS
      CCDS28895.1
      UniProtKB/TrEMBL
      Q91XL1
      Related
      ENSMUSP00000038048.8, ENSMUST00000041357.9
      Conserved Domains (4) summary
      smart00082
      Location:292338
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:74294
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6586
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:109169
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56426678..56428946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)