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    TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]

    Gene ID: 25817, updated on 10-Dec-2024

    Summary

    Official Symbol
    TAFA5provided by HGNC
    Official Full Name
    TAFA chemokine like family member 5provided by HGNC
    Primary source
    HGNC:HGNC:21592
    See related
    Ensembl:ENSG00000219438 MIM:617499; AllianceGenome:HGNC:21592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAFA-5; FAM19A5; UNQ5208; QLLK5208
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]
    Expression
    Biased expression in brain (RPKM 13.2), endometrium (RPKM 3.4) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TAFA5 in Genome Data Viewer
    Location:
    22q13.32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (48489553..48751932)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (48982039..49245797)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (48885365..49147744)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373081 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48765615-48766210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48772927-48773431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48772420-48772926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48792732-48793724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48810064-48810602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48810603-48811140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48819797-48820788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48828944-48829484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48831787-48832288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19276 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:48841523-48842722 Neighboring gene uncharacterized LOC124905142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48887443-48887948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48890918-48891778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48892641-48893500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48895067-48895980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48902339-48903338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48906445-48907385 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48907386-48908325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48911142-48911882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48918523-48919026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48923229-48923730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48923731-48924230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48929759-48930260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48930261-48930760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48933150-48933964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48943879-48944378 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:48953988-48954215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48956269-48957157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48955380-48956268 Neighboring gene uncharacterized LOC284933 Neighboring gene uncharacterized LOC124900480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48972958-48973464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49001381-49002302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49024390-49025219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49025220-49026048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49026049-49026878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49030484-49031058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49031059-49031631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49036799-49037318 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:49043107-49043284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49062165-49062666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49062667-49063166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49064778-49065430 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63487 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49096987-49097494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49097495-49098002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49107619-49108118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49113659-49114248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49114249-49114838 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:49191875-49192796 Neighboring gene microRNA 4535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49232881-49233408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49252199-49252698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49264603-49265104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49265105-49265604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49267795-49268295 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63550 Neighboring gene long intergenic non-protein coding RNA 1310

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (16 hits/1254 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
    EBI GWAS Catalog
    Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding  
    enables G protein-coupled receptor binding PubMed 
    enables cytokine activity  
    enables receptor ligand activity  
    enables receptor ligand activity PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in extracellular space  
    located_in extracellular space PubMed 

    General protein information

    Preferred Names
    chemokine-like protein TAFA-5
    Names
    TAFA protein 5
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
    family with sequence similarity 19 member A5, C-C motif chemokine like
    protein FAM19A5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082967.3 → NP_001076436.1  chemokine-like protein TAFA-5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001076436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF131851, DB541899, Z83837
      Consensus CDS
      CCDS46728.1
      UniProtKB/Swiss-Prot
      A6NII9, B0QZ13, B0QZ14, B0QZ15, O95902, Q5H9C4, Q6UWC9, Q7Z5A7, Q8IXR8
      Related
      ENSP00000383933.2, ENST00000402357.6
      Conserved Domains (1) summary
      pfam12020
      Location:42 → 131
      TAFA; TAFA family
    2. NM_015381.7 → NP_056196.2  chemokine-like protein TAFA-5 isoform 2

      See identical proteins and their annotated locations for NP_056196.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK125256, DB541899, Z83837
      Consensus CDS
      CCDS46729.1
      UniProtKB/Swiss-Prot
      Q7Z5A7
      Related
      ENSP00000351043.5, ENST00000358295.9
      Conserved Domains (1) summary
      pfam12020
      Location:35 → 124
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      48489553..48751932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      48982039..49245797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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