Tent5c terminal nucleotidyltransferase 5C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tent5cprovided by MGI
Official Full Name: terminal nucleotidyltransferase 5Cprovided by MGI
Primary source: MGI:MGI:1921895
See related: Ensembl:ENSMUSG00000044468 AllianceGenome:MGI:1921895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam46c; 4930431B09Rik
Summary: Enables poly(A) RNA polymerase activity. Involved in mRNA stabilization. Acts upstream of or within in utero embryonic development. Located in cytoplasm. Is expressed in blood; lens; liver lobe; and pancreas. Orthologous to human TENT5C (terminal nucleotidyltransferase 5C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 107.5), liver E14.5 (RPKM 33.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 43.71 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (100375373..100396508, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (100468057..100489192, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
Title: Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in micedagger.
Title: Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice†.
TENT5C polyadenylates immunoglobulin mRNAs regulating their half-life and consequently steady-state levels and is upregulated in differentiating plasma cells by innate signaling
Title: Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C.
FAM46C protein is strongly induced during activation of primary splenocytes and that B lymphocytes isolated from newly generated FAM46C KO mice proliferate faster than those isolated from their WT littermates.
Title: The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10) 1 citation
Targeted (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492133

AI449797 (e-PCR)
- UniSTS:164214

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables poly(A) RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: terminal nucleotidyltransferase 5C

Names: DN-384L23.3; family with sequence similarity 46, member C; protein FAM46C; putative nucleotidyltransferase FAM46C

NP_001136424.1

EC 2.7.7.19

XP_006502275.1

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.