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    Lipc lipase C, hepatic type [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24538, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lipcprovided by RGD
    Official Full Name
    lipase C, hepatic typeprovided by RGD
    Primary source
    RGD:3009
    See related
    EnsemblRapid:ENSRNOG00000060338 AllianceGenome:RGD:3009
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including heparan sulfate proteoglycan binding activity; lipase activity; and lipoprotein particle binding activity. Involved in several processes, including glycerolipid metabolic process; low-density lipoprotein particle clearance; and plasma lipoprotein particle remodeling. Located in several cellular components, including cell surface; endosome; and microvillus. Used to study several diseases, including end stage renal disease; hepatitis; hyperinsulinism; obesity; and protein-energy malnutrition. Biomarker of ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1092.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lipc in Genome Data Viewer
    Location:
    8q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (80390470..80516463, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (71509633..71635663, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (77272582..77398485, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551907 Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene ADAM metallopeptidase domain 10 Neighboring gene uncharacterized LOC120094202 Neighboring gene uncharacterized LOC134480203 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene HCLS1 associated protein X-1, pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC108746

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables apolipoprotein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables apolipoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chylomicron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparan sulfate proteoglycan binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipoprotein lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase A1 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase A1 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables triacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aflatoxin metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chylomicron remnant clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chylomicron remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in developmental growth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycerophospholipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in low-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in low-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutral lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylcholine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylserine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of plasma lipoprotein particle levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to acetate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to carbohydrate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to copper ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to magnesium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in very-low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in very-low-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very-low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hepatic triacylglycerol lipase
    Names
    HL
    hepatic lipase
    lipase member C
    lipase, hepatic
    lysophospholipase
    phospholipase A1
    NP_036729.2
    XP_006243421.1
    XP_006243422.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012597.2NP_036729.2  hepatic triacylglycerol lipase precursor

      See identical proteins and their annotated locations for NP_036729.2

      Status: PROVISIONAL

      Source sequence(s)
      BC088160
      UniProtKB/Swiss-Prot
      P07867
      UniProtKB/TrEMBL
      A0A0G2K8I7, Q5M895
      Related
      ENSRNOP00000074623.1, ENSRNOT00000082763.3
      Conserved Domains (3) summary
      cd00707
      Location:47346
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01758
      Location:353488
      PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
      pfam00151
      Location:18350
      Lipase; Lipase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      80390470..80516463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243359.5XP_006243421.1  hepatic triacylglycerol lipase isoform X1

      UniProtKB/Swiss-Prot
      P07867
      UniProtKB/TrEMBL
      A0A0G2K6S7
      Related
      ENSRNOP00000073927.1, ENSRNOT00000085349.3
      Conserved Domains (3) summary
      cd00707
      Location:47362
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01758
      Location:369504
      PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
      pfam00151
      Location:18366
      Lipase; Lipase
    2. XM_006243360.4XP_006243422.1  hepatic triacylglycerol lipase isoform X2

      See identical proteins and their annotated locations for XP_006243422.1

      UniProtKB/Swiss-Prot
      P07867
      UniProtKB/TrEMBL
      A0A0G2K8I7, Q5M895
      Conserved Domains (3) summary
      cd00707
      Location:47346
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01758
      Location:353488
      PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
      pfam00151
      Location:18350
      Lipase; Lipase