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    Srpk2 SRSF protein kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srpk2provided by RGD
    Official Full Name
    SRSF protein kinase 2provided by RGD
    Primary source
    RGD:1305107
    See related
    EnsemblRapid:ENSRNOG00000010601 AllianceGenome:RGD:1305107
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including R-loop processing; nuclear speck organization; and regulation of viral genome replication. Is active in presynapse. Orthologous to human SRPK2 (SRSF protein kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 161.8), Adrenal (RPKM 112.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srpk2 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (12356983..12548345)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (11464684..11655993)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7994025..8187455)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase 7 Neighboring gene small nucleolar RNA SNORD93 Neighboring gene uncharacterized LOC134486545 Neighboring gene lysine methyltransferase 2E Neighboring gene uncharacterized LOC120102473

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. Jang SW, et al. Cancer Res, 2008 Jun 15. PMID 18559500, Free PMC Article
    2. Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2. Arancibia D, et al. Cells, 2019 Oct 29. PMID 31671734, Free PMC Article
    3. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Karakama Y, et al. Antimicrob Agents Chemother, 2010 Aug. PMID 20498328, Free PMC Article
    4. Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. Nowak DG, et al. J Biol Chem, 2010 Feb 19. PMID 19906640, Free PMC Article
    5. Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. Kamachi M, et al. J Exp Med, 2002 Nov 4. PMID 12417631, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in R-loop processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear speck organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SRSF protein kinase 2
    Names
    SFRS protein kinase 2
    serine/arginine-rich protein specific kinase 2
    serine/threonine-protein kinase SRPK2
    NP_001100045.1
    XP_006235965.3
    XP_017448002.1
    XP_038963154.1
    XP_038963156.1
    XP_038963157.1
    XP_038963159.1
    XP_038963160.1
    XP_038963161.1
    XP_038963162.1
    XP_063141767.1
    XP_063141768.1
    XP_063141769.1
    XP_063141770.1
    XP_063141771.1
    XP_063141772.1
    XP_063141773.1
    XP_063141774.1
    XP_063141775.1
    XP_063141776.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106575.2 → NP_001100045.1  SRSF protein kinase 2

      See identical proteins and their annotated locations for NP_001100045.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161879
      UniProtKB/TrEMBL
      A6K588, B1WBT4, F7FC44
      Related
      ENSRNOP00000059855.2, ENSRNOT00000063994.5
      Conserved Domains (2) summary
      smart00220
      Location:79 → 224
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      12356983..12548345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592513.3 → XP_017448002.1  SRSF protein kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JX62

    2. XM_063285699.1 → XP_063141769.1  SRSF protein kinase 2 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JX62, A0A8I6GM61
      Related
      ENSRNOP00000111066.1, ENSRNOT00000170847.1

    3. XM_063285698.1 → XP_063141768.1  SRSF protein kinase 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JX62

    4. XM_063285701.1 → XP_063141771.1  SRSF protein kinase 2 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JX62

    5. XM_039107232.2 → XP_038963160.1  SRSF protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JX62
      Related
      ENSRNOP00000070149.2, ENSRNOT00000080811.3
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 380
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    6. XM_039107226.2 → XP_038963154.1  SRSF protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX62
      Conserved Domains (2) summary
      TIGR00927
      Location:338 → 417
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:103 → 291
      PKc_like; Protein Kinases, catalytic domain

    7. XM_039107229.2 → XP_038963157.1  SRSF protein kinase 2 isoform X5

      UniProtKB/TrEMBL
      A6K588
      Related
      ENSRNOP00000080095.2, ENSRNOT00000108014.2
      Conserved Domains (2) summary
      TIGR00927
      Location:338 → 417
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:103 → 291
      PKc_like; Protein Kinases, catalytic domain

    8. XM_039107228.2 → XP_038963156.1  SRSF protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX62
      Conserved Domains (2) summary
      TIGR00927
      Location:329 → 408
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:103 → 282
      PKc_like; Protein Kinases, catalytic domain

    9. XM_039107233.2 → XP_038963161.1  SRSF protein kinase 2 isoform X9

      UniProtKB/TrEMBL
      A6K588
      Conserved Domains (2) summary
      TIGR00927
      Location:329 → 408
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:529 → 707
      PKc_like; Protein Kinases, catalytic domain

    10. XM_039107231.2 → XP_038963159.1  SRSF protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JX62
      Conserved Domains (2) summary
      TIGR00927
      Location:301 → 380
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:66 → 254
      PKc_like; Protein Kinases, catalytic domain

    11. XM_063285702.1 → XP_063141772.1  SRSF protein kinase 2 isoform X14

      UniProtKB/TrEMBL
      A6K588, B1WBT4, F7FC44

    12. XM_063285705.1 → XP_063141775.1  SRSF protein kinase 2 isoform X17

      UniProtKB/TrEMBL
      A0A0G2JX62

    13. XM_039107234.2 → XP_038963162.1  SRSF protein kinase 2 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JX62, A0A8I5ZPE5
      Related
      ENSRNOP00000096635.2, ENSRNOT00000106508.2
      Conserved Domains (2) summary
      TIGR00927
      Location:312 → 391
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl21453
      Location:77 → 265
      PKc_like; Protein Kinases, catalytic domain

    14. XM_063285697.1 → XP_063141767.1  SRSF protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JX62
      Related
      ENSRNOP00000102557.1, ENSRNOT00000162564.1

    15. XM_063285700.1 → XP_063141770.1  SRSF protein kinase 2 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JX62

    16. XM_006235903.5 → XP_006235965.3  SRSF protein kinase 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JX62

    17. XM_063285703.1 → XP_063141773.1  SRSF protein kinase 2 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JX62

    18. XM_063285704.1 → XP_063141774.1  SRSF protein kinase 2 isoform X16

      UniProtKB/TrEMBL
      A6K588

    19. XM_063285706.1 → XP_063141776.1  SRSF protein kinase 2 isoform X18

    Nucleotide Protein Strain
    Heading Accession and Version

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