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    Uba2 ubiquitin-like modifier activating enzyme 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uba2provided by RGD
    Official Full Name
    ubiquitin-like modifier activating enzyme 2provided by RGD
    Primary source
    RGD:1312023
    See related
    EnsemblRapid:ENSRNOG00000021113 AllianceGenome:RGD:1312023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sae2; Uble1b
    Summary
    Predicted to enable several functions, including ATP binding activity; SUMO activating enzyme activity; and enzyme binding activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Predicted to be located in nucleoplasm. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 407.3), Spleen (RPKM 282.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uba2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95912422..95939870, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86775239..86802685, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90010681..90035522, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1B, member 30 Neighboring gene WT1 interacting protein Neighboring gene small nucleolar RNA SNORA11 Neighboring gene programmed cell death 2-like Neighboring gene glucose-6-phosphate isomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. Desterro JM, et al. J Biol Chem, 1999 Apr 9. PMID 10187858
    2. Active site remodelling accompanies thioester bond formation in the SUMO E1. Olsen SK, et al. Nature, 2010 Feb 18. PMID 20164921, Free PMC Article
    3. Ribosomal protein S3 is stabilized by sumoylation. Jang CY, et al. Biochem Biophys Res Commun, 2011 Oct 28. PMID 21968017
    4. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Ban R, et al. Genes Cells, 2011 Jun. PMID 21554500
    5. Ikaros SUMOylation: switching out of repression. Gómez-del Arco P, et al. Mol Cell Biol, 2005 Apr. PMID 15767674, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to SUMO activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SUMO activating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-activating enzyme subunit 2
    Names
    SUMO1 activating enzyme subunit 2
    ubiquitin-like 1 (sentrin) activating enzyme E1B
    NP_001094049.1
    XP_038967529.1
    XP_063117687.1
    XP_063117691.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100579.1 → NP_001094049.1  SUMO-activating enzyme subunit 2

      See identical proteins and their annotated locations for NP_001094049.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161985
      UniProtKB/TrEMBL
      A0A8I6A3Z5, B1WC32
      Related
      ENSRNOP00000028672.9, ENSRNOT00000028672.9
      Conserved Domains (4) summary
      cd01489
      Location:19 → 443
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:9 → 175
      ThiF; ThiF family
      pfam14732
      Location:451 → 537
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:548 → 634
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95912422..95939870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261617.1 → XP_063117687.1  SUMO-activating enzyme subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3Z5
      Related
      ENSRNOP00000087889.1, ENSRNOT00000101711.2

    2. XM_039111601.2 → XP_038967529.1  SUMO-activating enzyme subunit 2 isoform X1

      UniProtKB/TrEMBL
      F1LS72
      Related
      ENSRNOP00000109327.1, ENSRNOT00000130156.1
      Conserved Domains (4) summary
      cd01489
      Location:19 → 443
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam10585
      Location:179 → 361
      UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
      pfam14732
      Location:451 → 537
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:548 → 579
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    3. XM_063261621.1 → XP_063117691.1  SUMO-activating enzyme subunit 2 isoform X3

    RNA

    1. XR_010052057.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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