Inmt indolethylamine N-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inmtprovided by RGD
Official Full Name: indolethylamine N-methyltransferaseprovided by RGD
Primary source: RGD:1597087
See related: EnsemblRapid:ENSRNOG00000011250 AllianceGenome:RGD:1597087
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable N-methyltransferase activity; amine N-methyltransferase activity; and thioether S-methyltransferase activity. Predicted to be involved in amine metabolic process and methylation. Predicted to be active in cytosol. Orthologous to human INMT (indolethylamine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 542.3), Uterus (RPKM 170.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85648459..85652755, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84318197..84322493, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85381907..85386203, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats.
Title: Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables thioether S-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioether S-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: indolethylamine N-methyltransferase

NP_001102492.1

EC 2.1.1.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.