Rab2b RAB2B, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab2bprovided by RGD
Official Full Name: RAB2B, member RAS oncogene familyprovided by RGD
Primary source: RGD:1309117
See related: EnsemblRapid:ENSRNOG00000012488 AllianceGenome:RGD:1309117
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of exocytosis; and positive regulation of type I interferon production. Located in presynapse. Orthologous to human RAB2B (RAB2B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 97.1), Kidney (RPKM 81.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (27441860..27462479, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24968364..24988990, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28675504..28696192, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-2B

NP_001032734.1

EC 3.6.5.2

XP_038949207.1

EC 3.6.5.2

XP_038949210.1

EC 3.6.5.2

XP_063130300.1

EC 3.6.5.2

XP_063130301.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037645.1 → NP_001032734.1 ras-related protein Rab-2B

See identical proteins and their annotated locations for NP_001032734.1

Status: PROVISIONAL

Source sequence(s)

BC107443

UniProtKB/TrEMBL

A0A8I6G3N4, A6KEG9, A6KEH0, Q3B7V5

Related

ENSRNOP00000057211.3, ENSRNOT00000060467.6

Conserved Domains (1) summary

PLN03108
Location:1 → 215

PLN03108; Rab family protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

27441860..27462479 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093282.2 → XP_038949210.1 ras-related protein Rab-2B isoform X4

Conserved Domains (1) summary

PLN03108
Location:1 → 119

PLN03108; Rab family protein; Provisional
XM_039093279.2 → XP_038949207.1 ras-related protein Rab-2B isoform X3

UniProtKB/TrEMBL

A0A8I6A284

Related

ENSRNOP00000084964.1, ENSRNOT00000119568.2

Conserved Domains (1) summary

cl38936
Location:3 → 120

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_063274231.1 → XP_063130301.1 ras-related protein Rab-2B isoform X2
XM_063274230.1 → XP_063130300.1 ras-related protein Rab-2B isoform X1

UniProtKB/TrEMBL

A0A8I5ZKQ1, A0A8I6G3N4

Related

ENSRNOP00000079725.2, ENSRNOT00000106538.2