Kank2 KN motif and ankyrin repeat domains 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kank2provided by RGD
Official Full Name: KN motif and ankyrin repeat domains 2provided by RGD
Primary source: RGD:2320289
See related: EnsemblRapid:ENSRNOG00000010643 AllianceGenome:RGD:2320289
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563532
Summary: Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; podocyte cell migration; and regulation of intracellular signal transduction. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16 and palmoplantar keratoderma and woolly hair. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 355.2), Lung (RPKM 228.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (28587770..28617212, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20311676..20341107, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (22792000..22821459, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
Title: CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-kappaB p65 inhibition.
Title: Therapeutic effects of KANK2 in myocardial infarction rats might be associated with the NF-κB p65 inhibition.
In rats, KANK1, KANK2, and KANK4 all localized to podocytes in glomeruli, and KANK1 partially colocalized with synaptopodin.
Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133408 (e-PCR)
- UniSTS:216691

RH130874 (e-PCR)
- UniSTS:214158

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in kidney epithelium development	IEA Inferred from Electronic Annotation more info
involved_in kidney epithelium development	ISO Inferred from Sequence Orthology more info
involved_in kidney epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vitamin D receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vitamin D receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vitamin D receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	IEA Inferred from Electronic Annotation more info
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KN motif and ankyrin repeat domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270413.1 → NP_001257342.1 KN motif and ankyrin repeat domain-containing protein 2

See identical proteins and their annotated locations for NP_001257342.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8L2QNK4, A6JNU5, D4ACC2

Conserved Domains (6) summary

cd00204
Location:650 → 781

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12075
Location:31 → 59

KN_motif; KN motif

pfam12796
Location:660 → 758

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:631 → 676

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:747 → 802

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:728 → 758

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

28587770..28617212 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242589.5 → XP_006242651.1 KN motif and ankyrin repeat domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006242651.1

UniProtKB/Swiss-Prot

D3ZD05

UniProtKB/TrEMBL

A0A8L2QNK4

Conserved Domains (5) summary

cd00204
Location:657 → 788

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:735 → 765

ANK; ANK repeat [structural motif]

pfam12075
Location:31 → 59

KN_motif; KN motif

pfam12796
Location:624 → 687

Ank_2; Ankyrin repeats (3 copies)

cl00478
Location:438 → 580

LGT; Prolipoprotein diacylglyceryl transferase
XM_006242590.5 → XP_006242652.1 KN motif and ankyrin repeat domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006242652.1

UniProtKB/Swiss-Prot

D3ZD05

UniProtKB/TrEMBL

A0A8L2QNK4

Related

ENSRNOP00000014135.6, ENSRNOT00000014135.9

Conserved Domains (5) summary

cd00204
Location:657 → 788

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:735 → 765

ANK; ANK repeat [structural motif]

pfam12075
Location:31 → 59

KN_motif; KN motif

pfam12796
Location:624 → 687

Ank_2; Ankyrin repeats (3 copies)

cl00478
Location:438 → 580

LGT; Prolipoprotein diacylglyceryl transferase
XM_063264709.1 → XP_063120779.1 KN motif and ankyrin repeat domain-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

D3ZD05

UniProtKB/TrEMBL

A0A8L2QNK4