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    Fubp1 far upstream element binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 654496, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fubp1provided by RGD
    Official Full Name
    far upstream element binding protein 1provided by RGD
    Primary source
    RGD:1591892
    See related
    EnsemblRapid:ENSRNOG00000043370 AllianceGenome:RGD:1591892
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mRNA binding activity. Involved in cellular response to lipopolysaccharide; positive regulation of Schwann cell migration; and response to nutrient levels. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; nucleus; and synapse. Biomarker of sciatic neuropathy and traumatic brain injury. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human FUBP1 (far upstream element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 308.1), Spleen (RPKM 233.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fubp1 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243819529..243846544)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241159481..241186591)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257425676..257452745)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S10 pseudogene Neighboring gene GIPC PDZ domain containing family, member 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B4 Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene nexilin (F actin binding protein) Neighboring gene mitoguardin 1 Neighboring gene uncharacterized LOC120100974

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    far upstream element-binding protein 1
    Names
    FBP
    FUSE-binding protein 1
    far upstream element (FUSE) binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037653.1NP_001032742.1  far upstream element-binding protein 1

      See identical proteins and their annotated locations for NP_001032742.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107942
      UniProtKB/Swiss-Prot
      Q32PX7
      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (2) summary
      cd00105
      Location:97159
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam09005
      Location:603617
      DUF1897; Domain of unknown function (DUF1897)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      243819529..243846544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103100.2XP_038959028.1  far upstream element-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:628642
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:115189
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:203272
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:293360
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:393464
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    2. XM_039103105.2XP_038959033.1  far upstream element-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:628642
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:115189
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:203272
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:293360
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:393464
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    3. XM_039103102.2XP_038959030.1  far upstream element-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:625639
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:115189
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:203272
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:293360
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:393464
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    4. XM_039103101.2XP_038959029.1  far upstream element-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:627641
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:114188
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:202271
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:292359
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:392463
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    5. XM_039103103.2XP_038959031.1  far upstream element-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:624638
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:114188
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:202271
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:292359
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:392463
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    6. XM_039103106.2XP_038959034.1  far upstream element-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:607621
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:94168
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:182251
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:272339
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:372443
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    7. XM_039103108.2XP_038959036.1  far upstream element-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:604618
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:94168
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:182251
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:272339
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:372443
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    8. XM_039103107.2XP_038959035.1  far upstream element-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A140TAJ3, A0A8I5YBV8
      Related
      ENSRNOP00000077531.1, ENSRNOT00000094623.2
      Conserved Domains (5) summary
      pfam09005
      Location:606620
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:93167
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:181250
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:271338
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:371442
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    9. XM_063282511.1XP_063138581.1  far upstream element-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A140TAJ3
      Related
      ENSRNOP00000061544.5, ENSRNOT00000066199.5
    10. XM_039103109.2XP_038959037.1  far upstream element-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A140TAJ3
    11. XM_063282512.1XP_063138582.1  far upstream element-binding protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A140TAJ3
    12. XM_006233507.5XP_006233569.1  far upstream element-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (2) summary
      cd00105
      Location:119181
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam09005
      Location:628642
      DUF1897; Domain of unknown function (DUF1897)
    13. XM_006233511.5XP_006233573.1  far upstream element-binding protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (2) summary
      cd00105
      Location:119181
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam09005
      Location:628642
      DUF1897; Domain of unknown function (DUF1897)
    14. XM_063282510.1XP_063138580.1  far upstream element-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A140TAJ3
    15. XM_006233512.5XP_006233574.1  far upstream element-binding protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (2) summary
      cd00105
      Location:119181
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam09005
      Location:625639
      DUF1897; Domain of unknown function (DUF1897)
    16. XM_063282508.1XP_063138578.1  far upstream element-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A140TAJ3
    17. XM_039103111.2XP_038959039.1  far upstream element-binding protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:627641
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:114188
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:202271
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:292359
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:392463
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    18. XM_039103110.2XP_038959038.1  far upstream element-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (5) summary
      pfam09005
      Location:624638
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:114188
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:202271
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:292359
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:392463
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    19. XM_039103113.2XP_038959041.1  far upstream element-binding protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A140TAJ3
      Related
      ENSRNOP00000099811.1, ENSRNOT00000157036.1
      Conserved Domains (5) summary
      pfam09005
      Location:624638
      DUF1897; Domain of unknown function (DUF1897)
      cd22478
      Location:114188
      KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22481
      Location:202271
      KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22484
      Location:292359
      KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
      cd22487
      Location:392463
      KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
    20. XM_008761555.4XP_008759777.1  far upstream element-binding protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (2) summary
      pfam09005
      Location:607621
      DUF1897; Domain of unknown function (DUF1897)
      cl00098
      Location:94168
      KH-I; K homology (KH) RNA-binding domain, type I
    21. XM_063282515.1XP_063138585.1  far upstream element-binding protein 1 isoform X24

      UniProtKB/TrEMBL
      A0A140TAJ3
      Related
      ENSRNOP00000111951.1, ENSRNOT00000135698.1
    22. XM_006233513.5XP_006233575.1  far upstream element-binding protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A140TAJ3
      Related
      ENSRNOP00000103007.1, ENSRNOT00000132758.1
      Conserved Domains (2) summary
      pfam09005
      Location:604618
      DUF1897; Domain of unknown function (DUF1897)
      cl00098
      Location:94168
      KH-I; K homology (KH) RNA-binding domain, type I
    23. XM_063282517.1XP_063138587.1  far upstream element-binding protein 1 isoform X26

      UniProtKB/TrEMBL
      A0A140TAJ3
    24. XM_008761556.4XP_008759778.1  far upstream element-binding protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A140TAJ3
      Conserved Domains (2) summary
      pfam09005
      Location:606620
      DUF1897; Domain of unknown function (DUF1897)
      cl00098
      Location:93167
      KH-I; K homology (KH) RNA-binding domain, type I
    25. XM_063282516.1XP_063138586.1  far upstream element-binding protein 1 isoform X25

      UniProtKB/TrEMBL
      A0A140TAJ3
      Related
      ENSRNOP00000095243.2, ENSRNOT00000110491.2
    26. XM_063282514.1XP_063138584.1  far upstream element-binding protein 1 isoform X23

      UniProtKB/TrEMBL
      A0A140TAJ3

    RNA

    1. XR_005500367.2 RNA Sequence