U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pnpla6 patatin-like phospholipase domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360753, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pnpla6provided by RGD
    Official Full Name
    patatin-like phospholipase domain containing 6provided by RGD
    Primary source
    RGD:1564611
    See related
    EnsemblRapid:ENSRNOG00000000977 AllianceGenome:RGD:1564611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564611
    Summary
    Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process and phosphatidylcholine metabolic process. Predicted to act upstream of or within angiogenesis and animal organ morphogenesis. Predicted to be located in cytosol and membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to human PNPLA6 (patatin like phospholipase domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 66.1), Brain (RPKM 51.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pnpla6 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6372284..6401632)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1574387..1603735)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2068749..2098139)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 358 Neighboring gene mucolipin TRP cation channel 1 Neighboring gene uncharacterized LOC120095868 Neighboring gene calmodulin regulated spectrin-associated protein family, member 3 Neighboring gene XPA binding protein 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers. McFerrin J, et al. Glia, 2017 May. PMID 28206686, Free PMC Article
    2. Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells. Li Y, et al. J Biol Chem, 2003 Mar 7. PMID 12514188
    3. Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells. Zaccheo O, et al. J Biol Chem, 2004 Jun 4. PMID 15044461
    4. Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. Kienesberger PC, et al. J Biol Chem, 2008 Feb 29. PMID 18086666
    5. Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Moser M, et al. Mol Cell Biol, 2004 Feb. PMID 14749382, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lysophospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    patatin-like phospholipase domain-containing protein 6
    Names
    neuropathy target esterase
    NP_001414056.1
    NP_001414057.1
    XP_008767227.2
    XP_008767229.1
    XP_008767230.1
    XP_008767231.2
    XP_008767232.2
    XP_008767234.1
    XP_038945821.1
    XP_038945823.1
    XP_038945825.1
    XP_063127495.1
    XP_063127496.1
    XP_063127497.1
    XP_063127498.1
    XP_063127499.1
    XP_063127500.1
    XP_063127501.1
    XP_063127503.1
    XP_063127504.1
    XP_063127505.1
    XP_063127506.1
    XP_063127507.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427127.1 → NP_001414056.1  patatin-like phospholipase domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6KQ10
      Related
      ENSRNOP00000105327.1, ENSRNOT00000143082.1

    2. NM_001427128.1 → NP_001414057.1  patatin-like phospholipase domain-containing protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6KQ10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      6372284..6401632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769010.4 → XP_008767232.2  patatin-like phospholipase domain-containing protein 6 isoform X12

      UniProtKB/TrEMBL
      A6KQ10, D3ZRF6
      Conserved Domains (4) summary
      cd07225
      Location:938 → 1243
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:162 → 304
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:943 → 1227
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:609 → 717
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. XM_063271431.1 → XP_063127501.1  patatin-like phospholipase domain-containing protein 6 isoform X10

      UniProtKB/TrEMBL
      A6KQ10

    3. XM_008769009.4 → XP_008767231.2  patatin-like phospholipase domain-containing protein 6 isoform X12

      UniProtKB/TrEMBL
      A6KQ10, D3ZRF6
      Conserved Domains (4) summary
      cd07225
      Location:938 → 1243
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:162 → 304
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:943 → 1227
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:609 → 717
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    4. XM_063271436.1 → XP_063127506.1  patatin-like phospholipase domain-containing protein 6 isoform X14

      UniProtKB/TrEMBL
      A6KQ10

    5. XM_063271434.1 → XP_063127504.1  patatin-like phospholipase domain-containing protein 6 isoform X13

      UniProtKB/TrEMBL
      A6KQ09, A6KQ10

    6. XM_063271430.1 → XP_063127500.1  patatin-like phospholipase domain-containing protein 6 isoform X10

      UniProtKB/TrEMBL
      A6KQ10

    7. XM_008769012.4 → XP_008767234.1  patatin-like phospholipase domain-containing protein 6 isoform X13

      See identical proteins and their annotated locations for XP_008767234.1

      UniProtKB/TrEMBL
      A6KQ09, A6KQ10
      Conserved Domains (4) summary
      cd07225
      Location:937 → 1242
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:162 → 304
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:942 → 1226
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:609 → 717
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    8. XM_039089897.2 → XP_038945825.1  patatin-like phospholipase domain-containing protein 6 isoform X15

      UniProtKB/TrEMBL
      A6KQ10
      Conserved Domains (2) summary
      cd07225
      Location:933 → 1238
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      cd00038
      Location:605 → 713
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    9. XM_063271437.1 → XP_063127507.1  patatin-like phospholipase domain-containing protein 6 isoform X16

      UniProtKB/TrEMBL
      A6KQ10

    10. XM_063271433.1 → XP_063127503.1  patatin-like phospholipase domain-containing protein 6 isoform X12

      UniProtKB/TrEMBL
      A6KQ10, D3ZRF6

    11. XM_063271435.1 → XP_063127505.1  patatin-like phospholipase domain-containing protein 6 isoform X13

      UniProtKB/TrEMBL
      A6KQ09, A6KQ10

    12. XM_063271425.1 → XP_063127495.1  patatin-like phospholipase domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A6KQ10

    13. XM_008769005.4 → XP_008767227.2  patatin-like phospholipase domain-containing protein 6 isoform X7

      UniProtKB/TrEMBL
      A6KQ10

    14. XM_063271426.1 → XP_063127496.1  patatin-like phospholipase domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A6KQ10

    15. XM_008769007.4 → XP_008767229.1  patatin-like phospholipase domain-containing protein 6 isoform X6

      See identical proteins and their annotated locations for XP_008767229.1

      UniProtKB/TrEMBL
      A6KQ10
      Related
      ENSRNOP00000065231.3, ENSRNOT00000072952.3
      Conserved Domains (4) summary
      cd07225
      Location:949 → 1254
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:173 → 315
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:954 → 1238
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:620 → 728
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    16. XM_039089893.2 → XP_038945821.1  patatin-like phospholipase domain-containing protein 6 isoform X9

      UniProtKB/TrEMBL
      A6KQ10
      Conserved Domains (2) summary
      cd07225
      Location:948 → 1253
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      cd00038
      Location:620 → 728
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    17. XM_063271427.1 → XP_063127497.1  patatin-like phospholipase domain-containing protein 6 isoform X3

      UniProtKB/TrEMBL
      A6KQ10

    18. XM_008769008.4 → XP_008767230.1  patatin-like phospholipase domain-containing protein 6 isoform X8

      See identical proteins and their annotated locations for XP_008767230.1

      UniProtKB/TrEMBL
      A6KQ10, M0R715
      Related
      ENSRNOP00000001298.7, ENSRNOT00000001298.9
      Conserved Domains (4) summary
      cd07225
      Location:948 → 1253
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:173 → 315
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:953 → 1237
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:620 → 728
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    19. XM_063271428.1 → XP_063127498.1  patatin-like phospholipase domain-containing protein 6 isoform X4

      UniProtKB/TrEMBL
      A6KQ10

    20. XM_063271429.1 → XP_063127499.1  patatin-like phospholipase domain-containing protein 6 isoform X5

      UniProtKB/TrEMBL
      A6KQ10

    21. XM_039089895.2 → XP_038945823.1  patatin-like phospholipase domain-containing protein 6 isoform X11

      UniProtKB/TrEMBL
      A6KQ10
      Conserved Domains (2) summary
      cd07225
      Location:944 → 1249
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      cd00038
      Location:616 → 724
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous