Stam2 signal transducing adaptor molecule 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stam2provided by RGD
Official Full Name: signal transducing adaptor molecule 2provided by RGD
Primary source: RGD:1311497
See related: EnsemblRapid:ENSRNOG00000027447 AllianceGenome:RGD:1311497
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol binding activity and ubiquitin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in endocytic vesicle. Orthologous to human STAM2 (signal transducing adaptor molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 141.1), Kidney (RPKM 138.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (57597557..57643915, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (37186145..37234810, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (38230676..38277433, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducing adapter molecule 2

Names: STAM-2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012085.1 → NP_001012085.1 signal transducing adapter molecule 2

See identical proteins and their annotated locations for NP_001012085.1

Status: PROVISIONAL

Source sequence(s)

BC083912

UniProtKB/Swiss-Prot

Q5XHY7

UniProtKB/TrEMBL

A0A8I5ZKD5, A6JF29

Related

ENSRNOP00000080484.1, ENSRNOT00000115523.2

Conserved Domains (4) summary

cd11963
Location:204 → 260

SH3_STAM2; Src homology 3 domain of Signal Transducing Adaptor Molecule 2

cd03568
Location:9 → 143

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

pfam02809
Location:166 → 181

UIM; Ubiquitin interaction motif

pfam03127
Location:294 → 367

GAT; GAT domain