Rhbdd1 rhomboid domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhbdd1provided by RGD
Official Full Name: rhomboid domain containing 1provided by RGD
Primary source: RGD:1306477
See related: EnsemblRapid:ENSRNOG00000054963 AllianceGenome:RGD:1306477
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RRP4; rRHBDD1; RGD1306477
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein metabolic process. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum. Orthologous to human RHBDD1 (rhomboid domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 59.2), Adrenal (RPKM 45.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (91076786..91196719)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (83630037..83748690)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (88110731..88229462)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in cellular response to unfolded protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein intracellular domain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane protein proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein proteolysis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in membrane protein proteolysis involved in retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of male germ cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatid differentiation	ISO Inferred from Sequence Orthology more info
involved_in spermatid differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum quality control compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum quality control compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rhomboid-related protein 4

Names: rhomboid domain-containing protein 1; rhomboid-like protein 4

NP_001020062.1

EC 3.4.21.105

XP_008765472.1

EC 3.4.21.105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024891.2 → NP_001020062.1 rhomboid-related protein 4

See identical proteins and their annotated locations for NP_001020062.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q4V8F3

UniProtKB/TrEMBL

A0A8L2R1V2

Related

ENSRNOP00000073441.3, ENSRNOT00000077265.3

Conserved Domains (1) summary

cl21536
Location:61 → 206

Rhomboid; Rhomboid family
NM_001432019.1 → NP_001418948.1 rhomboid-related protein 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q4V8F3

UniProtKB/TrEMBL

A0A8L2R1V2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

91076786..91196719

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767250.4 → XP_008765472.1 rhomboid-related protein 4 isoform X1

Related

ENSRNOP00000082541.1, ENSRNOT00000107081.2

Conserved Domains (1) summary

cl21536
Location:61 → 206

Rhomboid; Rhomboid family