Gipc2 GIPC PDZ domain containing family, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gipc2provided by RGD
Full Name: GIPC PDZ domain containing family, member 2provided by RGD
Primary source: RGD:1560751
See related: EnsemblRapid:ENSRNOG00000042152 AllianceGenome:RGD:1560751
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be located in cytoplasm. Orthologous to human GIPC2 (GIPC PDZ domain containing family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 109.0), Lung (RPKM 55.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (243690742..243770199, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (241030764..241110236, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (257293161..257377982, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PDZ domain-containing protein GIPC2

Names: semaF cytoplasmic domain associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037210.1 → NP_001032287.1 PDZ domain-containing protein GIPC2

See identical proteins and their annotated locations for NP_001032287.1

Status: PROVISIONAL

Source sequence(s)

BC100257

UniProtKB/Swiss-Prot

Q498D9

UniProtKB/TrEMBL

A6HWJ8, F1M018

Related

ENSRNOP00000063118.4, ENSRNOT00000065811.5

Conserved Domains (2) summary

cd00992
Location:116 → 179

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd21180
Location:243 → 307

GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

243690742..243770199 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102808.2 → XP_038958736.1 PDZ domain-containing protein GIPC2 isoform X1

Conserved Domains (2) summary

cd21180
Location:160 → 224

GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family

cl00117
Location:59 → 96

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...