Ttpa alpha tocopherol transfer protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ttpaprovided by RGD
Full Name: alpha tocopherol transfer proteinprovided by RGD
Primary source: RGD:3915
See related: EnsemblRapid:ENSRNOG00000007139 AllianceGenome:RGD:3915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TTP; alpha-TTP
Summary: Enables vitamin E binding activity. Involved in several processes, including intracellular pH reduction; negative regulation of epithelial cell apoptotic process; and response to pH. Located in late endosome. Biomarker of liver benign neoplasm. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 2733.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (38294415..38315471)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (33497537..33518936)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (34007926..34029315)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The reduced expression of hepatic alpha-TTP and CYP4F2 genes probably leads to decreased plasma alpha-tocopherol levels and elevated alpha-tocopherol levels in the liver of streptozotocin rats.
Title: α-Tocopherol status and altered expression of α-tocopherol-related proteins in streptozotocin-induced type 1 diabetes in rat models.
Liver X receptor regulates alpha-TTP expression through direct interaction with the alpha-TTP gene promoter, and it modulates circulating alpha-tocopherol levels.
Title: Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status.
The Goto-Kakizaki (GK) rats showed an increase of the hepatic expression of the alpha-TTP gene as compared with ... controls. ... the increased hepatic alpha-TTP gene expression levels may influence plasma alpha-tocopherol levels in the diabetic animals.
Title: α-Tocopherol status and expression of α-tocopherol transfer protein in type 2 diabetic Goto-Kakizaki rats.
alpha-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport.
Title: A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity.
findings show that intracellular processing of tocopherol involves a functional interaction between TTP and an ABC-type transporter.
Title: Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein.
TTP transports alpha-TCP and oral administration of TTP compensates for TTP in TTP-deficient mice
Title: Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transfer activity	IEA Inferred from Electronic Annotation more info
enables lipid transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables vitamin E binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin E binding	IDA Inferred from Direct Assay more info	PubMed
enables vitamin E binding	IEA Inferred from Electronic Annotation more info
enables vitamin E binding	ISO Inferred from Sequence Orthology more info
enables vitamin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in intermembrane lipid transfer	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular pH reduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of establishment of blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in vitamin E metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin E metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vitamin E metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin E metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin transport	IEA Inferred from Electronic Annotation more info
involved_in vitamin transport	ISO Inferred from Sequence Orthology more info
involved_in vitamin transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-tocopherol transfer protein

Names: Tocopherol transfer protein alpha; alpha-tocopherol transfer protein-like; tocopherol (alpha) transfer protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429356.1 → NP_001416285.1 alpha-tocopherol transfer protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6IID5
NM_001429357.1 → NP_001416286.1 alpha-tocopherol transfer protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6IID5
NM_013048.4 → NP_037180.1 alpha-tocopherol transfer protein isoform 1

See identical proteins and their annotated locations for NP_037180.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P41034

UniProtKB/TrEMBL

A0A8L2Q527, A6IID4

Related

ENSRNOP00000009611.3, ENSRNOT00000009611.4

Conserved Domains (2) summary

smart01100
Location:25 → 73

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

pfam00650
Location:99 → 248

CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

38294415..38315471

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109317.2 → XP_038965245.1 alpha-tocopherol transfer protein isoform X3

UniProtKB/TrEMBL

A0A8I6GHG2

Conserved Domains (1) summary

pfam00650
Location:73 → 222

CRAL_TRIO; CRAL/TRIO domain
XM_017593164.2 → XP_017448653.1 alpha-tocopherol transfer protein isoform X4

Conserved Domains (1) summary

pfam00650
Location:30 → 179

CRAL_TRIO; CRAL/TRIO domain
XM_063287196.1 → XP_063143266.1 alpha-tocopherol transfer protein isoform X2

UniProtKB/TrEMBL

A0A8I6GHG2

Related

ENSRNOP00000107412.1, ENSRNOT00000149952.1
XM_039109318.2 → XP_038965246.1 alpha-tocopherol transfer protein isoform X4

Conserved Domains (1) summary

pfam00650
Location:30 → 179

CRAL_TRIO; CRAL/TRIO domain
XM_017593163.3 → XP_017448652.2 alpha-tocopherol transfer protein isoform X1

UniProtKB/TrEMBL

A0A8I6GHG2

Conserved Domains (1) summary

pfam00650
Location:90 → 239

CRAL_TRIO; CRAL/TRIO domain
XM_039109319.2 → XP_038965247.1 alpha-tocopherol transfer protein isoform X5

Conserved Domains (1) summary

pfam00650
Location:25 → 151

CRAL_TRIO; CRAL/TRIO domain