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    Tafa1 TAFA chemokine like family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500266, updated on 9-Dec-2024

    Summary

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    Symbol
    Tafa1provided by RGD
    Full Name
    TAFA chemokine like family member 1provided by RGD
    Primary source
    RGD:1563030
    See related
    EnsemblRapid:ENSRNOG00000070575 AllianceGenome:RGD:1563030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam19a1; RGD1563030
    Summary
    Predicted to enable receptor ligand activity. Predicted to be involved in neuroblast differentiation; regulation of neuroblast proliferation; and regulation of signaling receptor activity. Predicted to be located in endoplasmic reticulum and extracellular space. Orthologous to human TAFA1 (TAFA chemokine like family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 60.1), Spleen (RPKM 18.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tafa1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (130294659..130799139)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (128738028..129244223)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (128818468..128942088)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene NOP2 nucleolar protein, pseudogene 4 Neighboring gene uncharacterized LOC102549269 Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 7 Neighboring gene nucleoporin 50, pseudogene 1 Neighboring gene uncharacterized LOC120102500 Neighboring gene uncharacterized LOC120102499 Neighboring gene RNA, U6 small nuclear 131 Neighboring gene TAFA chemokine like family member 4 Neighboring gene uncharacterized LOC134486820 Neighboring gene uncharacterized LOC134486821

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation. Zheng C, et al. FASEB J, 2018 May 25. PMID 29799787

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TAFA chemokine like family member 1; chemokine-like protein TAFA-1
    Names
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
    family with sequence similarity 19 member A1, C-C motif chemokine like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431830.1 → NP_001418759.1  TAFA chemokine like family member 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZYE4

    2. NM_001431831.1 → NP_001418760.1  TAFA chemokine like family member 1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZYE4

    3. NM_001431832.1 → NP_001418761.1  TAFA chemokine like family member 1 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      130294659..130799139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109030.2 → XP_038964958.1  chemokine-like protein TAFA-1 isoform X2

      Related
      ENSRNOP00000083056.1, ENSRNOT00000097372.2
      Conserved Domains (1) summary
      pfam12020
      Location:41 → 129
      TAFA; TAFA family

    2. XM_039109032.2 → XP_038964960.1  chemokine-like protein TAFA-1 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:40 → 128
      TAFA; TAFA family

    3. XM_039109031.2 → XP_038964959.1  chemokine-like protein TAFA-1 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:41 → 129
      TAFA; TAFA family
    Nucleotide Protein Strain
    Heading Accession and Version

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