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    Rab23 RAB23, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab23provided by RGD
    Official Full Name
    RAB23, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1306867
    See related
    EnsemblRapid:ENSRNOG00000012629 AllianceGenome:RGD:1306867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in several processes, including cellular defense response; negative regulation of protein import into nucleus; and organelle assembly. Predicted to act upstream of or within several processes, including embryonic morphogenesis; regulation of smoothened signaling pathway; and spinal cord dorsal/ventral patterning. Predicted to be located in several cellular components, including centrosome; cytosol; and phagocytic vesicle. Predicted to be active in autophagosome and endosome membrane. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human RAB23 (RAB23, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 113.7), Brain (RPKM 52.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab23 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (43440047..43463327)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (35943522..35967367)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (38469784..38496185, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene DNA primase subunit 2 Neighboring gene cofilin-2, pseudogene 2 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 5 Neighboring gene BAG cochaperone 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Jenkins D, et al. Am J Hum Genet, 2007 Jun. PMID 17503333, Free PMC Article
    2. Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization. Guo A, et al. J Neurosci Res, 2006 May 1. PMID 16463280
    3. The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. Nozawa T, et al. Cell Microbiol, 2012 Aug. PMID 22452336
    4. Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner. Chi S, et al. Cell Signal, 2012 Jun. PMID 22365972, Free PMC Article
    5. Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Günther T, et al. Development, 1994 Nov. PMID 7720556

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular defense response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in craniofacial suture morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dorsal/ventral neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-23
    NP_001102475.1
    XP_008765183.1
    XP_017452053.1
    XP_017452055.1
    XP_017452056.1
    XP_017452058.1
    XP_038939895.1
    XP_038939896.1
    XP_038939897.1
    XP_063123574.1
    XP_063123575.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109005.2 → NP_001102475.1  ras-related protein Rab-23

      See identical proteins and their annotated locations for NP_001102475.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      43440047..43463327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596564.3 → XP_017452053.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    2. XM_017596569.3 → XP_017452058.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    3. XM_008766961.4 → XP_008765183.1  ras-related protein Rab-23 isoform X1

      See identical proteins and their annotated locations for XP_008765183.1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    4. XM_039083967.2 → XP_038939895.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    5. XM_039083968.2 → XP_038939896.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    6. XM_017596566.3 → XP_017452055.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Related
      ENSRNOP00000072716.1, ENSRNOT00000090385.3
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    7. XM_039083969.2 → XP_038939897.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    8. XM_017596567.3 → XP_017452056.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
      Conserved Domains (1) summary
      cd04106
      Location:10 → 169
      Rab23_like; Rab GTPase family 23 (Rab23)-like

    9. XM_063267504.1 → XP_063123574.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5

    10. XM_063267505.1 → XP_063123575.1  ras-related protein Rab-23 isoform X1

      UniProtKB/TrEMBL
      A6IN92, D3ZRM5
    Nucleotide Protein Strain
    Heading Accession and Version

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