Kcnv2 potassium voltage-gated channel modifier subfamily V member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnv2provided by RGD
Official Full Name: potassium voltage-gated channel modifier subfamily V member 2provided by RGD
Primary source: RGD:1309271
See related: EnsemblRapid:ENSRNOG00000012566 AllianceGenome:RGD:1309271
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in retinal cone dystrophy 3B. Orthologous to human KCNV2 (potassium voltage-gated channel modifier subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 19.2), Lung (RPKM 6.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (234409067..234485894)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (224999552..225014062)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (245396880..245475011)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The present data provide evidence that the transcriptional regulation of Kcnv2 and Kv2.1 is a way through which the retinal clock system drives the functional adaptation of visual function to the marked daily changes in environmental lighting conditions.
Title: The retinal clock drives the expression of Kcnv2, a channel essential for visual function and cone survival.

Submit: New GeneRIF Correction

General gene information

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Markers

BE096685 (e-PCR)
- UniSTS:244046

RH137408 (e-PCR)
- UniSTS:219496

RH138582 (e-PCR)
- UniSTS:220669

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily V member 2

Names: potassium channel, subfamily V, member 2; potassium channel, voltage-gated modifier subfamily V, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106370.1 → NP_001099840.1 potassium voltage-gated channel subfamily V member 2

See identical proteins and their annotated locations for NP_001099840.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A6I0T3, D3ZZR6

Related

ENSRNOP00000016757.2, ENSRNOT00000016757.5

Conserved Domains (4) summary

smart00225
Location:106 → 197

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:304 → 520

Ion_trans; Ion transport protein

pfam07885
Location:433 → 508

Ion_trans_2; Ion channel

cl02518
Location:106 → 197

BTB; BTB/POZ domain