Cmklr1 chemerin chemokine-like receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cmklr1provided by RGD
Official Full Name: chemerin chemokine-like receptor 1provided by RGD
Primary source: RGD:69359
See related: EnsemblRapid:ENSRNOG00000000704 AllianceGenome:RGD:69359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including positive regulation of cold-induced thermogenesis; positive regulation of macrophage chemotaxis; and regulation of gene expression. Predicted to be active in plasma membrane. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 135.8), Heart (RPKM 38.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48634929..48687833)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42974462..43027321)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48743556..48796582)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.
Title: ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.
Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension.
Title: Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension.
HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia.
Title: HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia.
Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain.
Title: Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain.
Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats.
Title: Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats.
immune cells infiltrating the target organ differentially express CMKLR1 in response to dietary modulations and has determined a deleterious role for CMKLR1 expressed on T cells specifically in the Dahl SS rat.
Title: Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension.
This study found that chemerin and CMKLR1 protein levels were regulated in white adipose tissue by different conditions associated with metabolic changes such as nutritional status, sex steroids, pregnancy, and food composition.
Title: Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender.
CMKLR1 and GPR1 were widely expressed in vascular smooth muscle.
Title: Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
Synovium from saline-treated (control) rats expressed CHemR23. There was a significant reduction in ChemR23 expression in the synovium at both the earlier and later time points in osteoarthritis pain model animals compared with saline-treated controls.
Title: Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.
These studies support the idea that chemerin modifies sympathetic nerve-mediated contraction through ChemR23 and that ChemR23 may be endogenously activated.
Title: The adipokine chemerin amplifies electrical field-stimulated contraction in the isolated rat superior mesenteric artery.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled chemoattractant receptor activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adipokinetic hormone binding	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables complement receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chemerin-like receptor 1

Names: G-protein coupled chemoattractant-like receptor; G-protein coupled receptor DEZ; chemokine receptor-like 1; chemokine-like receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022218.2 → NP_071554.2 chemerin-like receptor 1

See identical proteins and their annotated locations for NP_071554.2

Status: VALIDATED

Source sequence(s)

CB707803, JAXUCZ010000012

UniProtKB/Swiss-Prot

G3V625, O35786

Related

ENSRNOP00000102773.1, ENSRNOT00000166562.1

Conserved Domains (1) summary

cd15116
Location:39 → 326

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

48634929..48687833

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249509.5 → XP_006249571.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006249571.1

UniProtKB/Swiss-Prot

G3V625, O35786

Related

ENSRNOP00000000893.2, ENSRNOT00000000893.5

Conserved Domains (1) summary

cd15116
Location:39 → 326

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006249508.4 → XP_006249570.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006249570.1

UniProtKB/Swiss-Prot

G3V625, O35786

Related

ENSRNOP00000109591.1, ENSRNOT00000158605.1

Conserved Domains (1) summary

cd15116
Location:39 → 326

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006249507.5 → XP_006249569.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006249569.1

UniProtKB/Swiss-Prot

G3V625, O35786

Conserved Domains (1) summary

cd15116
Location:39 → 326

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006249505.5 → XP_006249567.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006249567.1

UniProtKB/Swiss-Prot

G3V625, O35786

Related

ENSRNOP00000110285.1, ENSRNOT00000124979.1

Conserved Domains (1) summary

cd15116
Location:39 → 326

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006249506.5 → XP_006249568.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006249568.1

UniProtKB/Swiss-Prot

G3V625, O35786

Conserved Domains (1) summary

cd15116
Location:39 → 326

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors