U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    EIF4G3 eukaryotic translation initiation factor 4 gamma 3 [ Homo sapiens (human) ]

    Gene ID: 8672, updated on 27-Dec-2024

    Summary

    Official Symbol
    EIF4G3provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4 gamma 3provided by HGNC
    Primary source
    HGNC:HGNC:3298
    See related
    Ensembl:ENSG00000075151 MIM:603929; AllianceGenome:HGNC:3298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    eIF4G 3; eIF4GII; eIF-4G 3
    Summary
    The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
    Expression
    Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EIF4G3 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20806292..21176897, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20632859..21003583, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21132785..21503390, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054065-21054727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054728-21055389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21056983-21057676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21057677-21058368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21058590-21059262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21059263-21059933 Neighboring gene SH2 domain containing 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21112523-21112715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 376 Neighboring gene heterochromatin protein 1 binding protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21146362-21146862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21146863-21147363 Neighboring gene RNA, U7 small nuclear 200 pseudogene Neighboring gene uncharacterized LOC105376830 Neighboring gene uncharacterized LOC105376829 Neighboring gene NFE2L2 motif-containing MPRA enhancer 38 Neighboring gene Sharpr-MPRA regulatory region 2723 Neighboring gene microRNA 1256 Neighboring gene ribosomal protein S15a pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21394491-21394661 Neighboring gene MPRA-validated peak106 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 325 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 27 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21544531-21544736 Neighboring gene MPRA-validated peak108 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21562319-21562819 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:21587933-21589132 Neighboring gene uncharacterized LOC124903872 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21591626-21592452 Neighboring gene Sharpr-MPRA regulatory region 15718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21600579-21601078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21603224-21604202 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:21604203-21605179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21610131-21610992 Neighboring gene endothelin converting enzyme 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21615400-21615961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 326 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:21620661-21621860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21623064-21623668 Neighboring gene ECE1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA cap binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 4F complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in intracellular membraneless organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4 gamma 3
    Names
    eIF-4-gamma 3
    eIF-4-gamma II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047026.1 RefSeqGene

      Range
      5424..375842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198801.2NP_001185730.1  eukaryotic translation initiation factor 4 gamma 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB209119, AL031005, BC072413, BC094683, BF084093, CN402454
      Consensus CDS
      CCDS72723.1
      UniProtKB/TrEMBL
      A0A0A0MSA7, A0A8I5KT99
      Related
      ENSP00000383274.2, ENST00000400422.6
    2. NM_001198802.2NP_001185731.1  eukaryotic translation initiation factor 4 gamma 3 isoform 2

      See identical proteins and their annotated locations for NP_001185731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional in-frame smaller exon in the 5' coding region and lacks an in-frame larger exon in the middle coding region, as compared to variant 1. The resulting isoform (2) has an extra smaller segment in one region and lacks a larger segment in another region, as compared to isoform 1.
      Source sequence(s)
      AB209119, AL031005, BC072413, BC094683, BF084093, CN402454
      Consensus CDS
      CCDS55580.1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Related
      ENSP00000509941.1, ENST00000686579.1
      Conserved Domains (5) summary
      cd11559
      Location:14341562
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:27302
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12281340
      MA3; MA3 domain
      pfam02854
      Location:761989
      MIF4G; MIF4G domain
      cl17013
      Location:15411587
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    3. NM_001198803.2NP_001185732.1  eukaryotic translation initiation factor 4 gamma 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' UTR and an additional in-frame exon in the 5' coding region, and lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (4) has an extra internal segment and a distinct and much shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL358392, AL627311, BC030578
      Consensus CDS
      CCDS59192.1
      UniProtKB/Swiss-Prot
      O43432
      Related
      ENSP00000507819.1, ENST00000682284.1
    4. NM_001391892.1NP_001378821.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14281556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12221334
      MA3; MA3 domain
      pfam02854
      Location:755983
      MIF4G; MIF4G domain
      cl17013
      Location:15351581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    5. NM_001391893.1NP_001378822.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Related
      ENSP00000264211.7, ENST00000264211.13
      Conserved Domains (5) summary
      cd11559
      Location:14281556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12221334
      MA3; MA3 domain
      pfam02854
      Location:755983
      MIF4G; MIF4G domain
      cl17013
      Location:15351581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    6. NM_001391894.1NP_001378823.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14281556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12221334
      MA3; MA3 domain
      pfam02854
      Location:755983
      MIF4G; MIF4G domain
      cl17013
      Location:15351581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    7. NM_001391895.1NP_001378824.1  eukaryotic translation initiation factor 4 gamma 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL627311
      UniProtKB/TrEMBL
      B4DXR2
    8. NM_001391896.1NP_001378825.1  eukaryotic translation initiation factor 4 gamma 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14271506
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10295
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12211333
      MA3; MA3 domain
      pfam02854
      Location:754982
      MIF4G; MIF4G domain
      cl17013
      Location:14841533
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    9. NM_001391897.1NP_001378826.1  eukaryotic translation initiation factor 4 gamma 3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:13791507
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam05109
      Location:107322
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02847
      Location:11731285
      MA3; MA3 domain
      pfam02854
      Location:706934
      MIF4G; MIF4G domain
      cl17013
      Location:14861532
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    10. NM_001391898.1NP_001378827.1  eukaryotic translation initiation factor 4 gamma 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14391518
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:4307
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12331345
      MA3; MA3 domain
      pfam02854
      Location:766994
      MIF4G; MIF4G domain
      cl17013
      Location:14961545
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    11. NM_001391899.1NP_001378828.1  eukaryotic translation initiation factor 4 gamma 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14271555
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10295
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12211333
      MA3; MA3 domain
      pfam02854
      Location:754982
      MIF4G; MIF4G domain
      cl17013
      Location:15341580
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    12. NM_001391900.1NP_001378829.1  eukaryotic translation initiation factor 4 gamma 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Related
      ENSP00000489051.2, ENST00000634879.2
      Conserved Domains (5) summary
      cd11559
      Location:14271555
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10295
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12211333
      MA3; MA3 domain
      pfam02854
      Location:754982
      MIF4G; MIF4G domain
      cl17013
      Location:15341580
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    13. NM_001391901.1NP_001378830.1  eukaryotic translation initiation factor 4 gamma 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14351563
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:6334
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:12291341
      MA3; MA3 domain
      pfam02854
      Location:762990
      MIF4G; MIF4G domain
      cl17013
      Location:15421588
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    14. NM_001391902.1NP_001378831.1  eukaryotic translation initiation factor 4 gamma 3 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14651593
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:58333
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12591371
      MA3; MA3 domain
      pfam02854
      Location:7921020
      MIF4G; MIF4G domain
      cl17013
      Location:15721618
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    15. NM_001391903.1NP_001378832.1  eukaryotic translation initiation factor 4 gamma 3 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14651593
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:58333
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12591371
      MA3; MA3 domain
      pfam02854
      Location:7921020
      MIF4G; MIF4G domain
      cl17013
      Location:15721618
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    16. NM_001391904.1NP_001378833.1  eukaryotic translation initiation factor 4 gamma 3 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14651593
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12591371
      MA3; MA3 domain
      pfam02854
      Location:7921020
      MIF4G; MIF4G domain
      cl17013
      Location:15721618
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    17. NM_001391905.1NP_001378834.1  eukaryotic translation initiation factor 4 gamma 3 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS90875.1
      UniProtKB/TrEMBL
      A0A8I5KT99, A0A8I5QJH9
      Related
      ENSP00000509547.1, ENST00000688741.1
      Conserved Domains (5) summary
      cd11559
      Location:14761604
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12701382
      MA3; MA3 domain
      pfam02854
      Location:8031031
      MIF4G; MIF4G domain
      pfam03154
      Location:53368
      Atrophin-1; Atrophin-1 family
      cl17013
      Location:15831629
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    18. NM_001391906.1NP_001378835.1  eukaryotic translation initiation factor 4 gamma 3 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      Consensus CDS
      CCDS90876.1
      UniProtKB/TrEMBL
      A0A8I5KT99, A0A8J9G7U8
      Related
      ENSP00000473510.2, ENST00000602326.6
      Conserved Domains (5) summary
      cd11559
      Location:14841612
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:52383
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:12781390
      MA3; MA3 domain
      pfam02854
      Location:8111039
      MIF4G; MIF4G domain
      cl17013
      Location:15911637
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    19. NM_001391907.1NP_001378836.1  eukaryotic translation initiation factor 4 gamma 3 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL031005, AL358392, AL606477, AL627311
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:15141642
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:13081420
      MA3; MA3 domain
      pfam02854
      Location:8411069
      MIF4G; MIF4G domain
      pfam03154
      Location:53369
      Atrophin-1; Atrophin-1 family
      cl17013
      Location:16211667
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    20. NM_003760.4NP_003751.2  eukaryotic translation initiation factor 4 gamma 3 isoform 3

      See identical proteins and their annotated locations for NP_003751.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB209119, AF012072, BC094683, BF084093
      Consensus CDS
      CCDS214.1
      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14281556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:10296
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12221334
      MA3; MA3 domain
      pfam02854
      Location:755983
      MIF4G; MIF4G domain
      cl17013
      Location:15351581
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      20806292..21176897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433321.1XP_047289277.1  eukaryotic translation initiation factor 4 gamma 3 isoform X29

      UniProtKB/TrEMBL
      A0A8I5KT99
    2. XM_047433366.1XP_047289322.1  eukaryotic translation initiation factor 4 gamma 3 isoform X42

      UniProtKB/TrEMBL
      B4DH17
    3. XM_047433324.1XP_047289280.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

      UniProtKB/TrEMBL
      A0A8I5KT99
    4. XM_017002708.3XP_016858197.1  eukaryotic translation initiation factor 4 gamma 3 isoform X41

      UniProtKB/TrEMBL
      B4DH17
      Related
      ENSP00000364071.3, ENST00000374935.7
      Conserved Domains (4) summary
      cd11559
      Location:11481276
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:9421054
      MA3; MA3 domain
      pfam02854
      Location:475703
      MIF4G; MIF4G domain
      cl17013
      Location:12551301
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    5. XM_017002707.3XP_016858196.1  eukaryotic translation initiation factor 4 gamma 3 isoform X40

      UniProtKB/TrEMBL
      B4DZE1
      Conserved Domains (4) summary
      cd11559
      Location:11851313
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:9791091
      MA3; MA3 domain
      pfam02854
      Location:512740
      MIF4G; MIF4G domain
      cl17013
      Location:12921338
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    6. XM_047433340.1XP_047289296.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

      UniProtKB/TrEMBL
      A0A8I5KT99
    7. XM_011542370.3XP_011540672.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      See identical proteins and their annotated locations for XP_011540672.1

      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:15211649
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:52383
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:13151427
      MA3; MA3 domain
      pfam02854
      Location:8481076
      MIF4G; MIF4G domain
      cl17013
      Location:16281674
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    8. XM_047433231.1XP_047289187.1  eukaryotic translation initiation factor 4 gamma 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5KT99
      Related
      ENSP00000509442.1, ENST00000685872.1
    9. XM_047433319.1XP_047289275.1  eukaryotic translation initiation factor 4 gamma 3 isoform X28

      UniProtKB/Swiss-Prot
      B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
      UniProtKB/TrEMBL
      A0A8I5KT99
    10. XM_047433196.1XP_047289152.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KT99
    11. XM_047433323.1XP_047289279.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

      UniProtKB/TrEMBL
      A0A8I5KT99
    12. XM_047433348.1XP_047289304.1  eukaryotic translation initiation factor 4 gamma 3 isoform X36

      UniProtKB/TrEMBL
      A0A8I5KT99
    13. XM_047433337.1XP_047289293.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

      UniProtKB/TrEMBL
      A0A8I5KT99
    14. XM_047433345.1XP_047289301.1  eukaryotic translation initiation factor 4 gamma 3 isoform X35

      UniProtKB/TrEMBL
      A0A8I5KT99
    15. XM_047433329.1XP_047289285.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

      UniProtKB/TrEMBL
      A0A8I5KT99
    16. XM_047433291.1XP_047289247.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

      UniProtKB/TrEMBL
      A0A0A0MSA7, A0A8I5KT99
    17. XM_047433287.1XP_047289243.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

      UniProtKB/TrEMBL
      A0A8I5KT99
    18. XM_047433312.1XP_047289268.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14341562
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:27302
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12281340
      MA3; MA3 domain
      pfam02854
      Location:761989
      MIF4G; MIF4G domain
      cl17013
      Location:15411587
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    19. XM_047433274.1XP_047289230.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

      UniProtKB/TrEMBL
      A0A8I5KT99
    20. XM_047433296.1XP_047289252.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

      UniProtKB/TrEMBL
      A0A8I5KT99
    21. XM_047433294.1XP_047289250.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

      UniProtKB/TrEMBL
      A0A8I5KT99
    22. XM_011542371.3XP_011540673.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

      See identical proteins and their annotated locations for XP_011540673.1

      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:14761604
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PRK10263
      Location:4307
      PRK10263; DNA translocase FtsK; Provisional
      pfam02847
      Location:12701382
      MA3; MA3 domain
      pfam02854
      Location:8031031
      MIF4G; MIF4G domain
      cl17013
      Location:15831629
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    23. XM_047433261.1XP_047289217.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

      UniProtKB/TrEMBL
      A0A804HJV5, A0A8I5KT99
      Related
      ENSP00000507662.1, ENST00000684485.1
    24. XM_047433283.1XP_047289239.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

      UniProtKB/TrEMBL
      A0A8I5KT99
    25. XM_047433282.1XP_047289238.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

      UniProtKB/TrEMBL
      A0A8I5KT99
    26. XM_017002677.3XP_016858166.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5KT99
      Conserved Domains (5) summary
      cd11559
      Location:15031631
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12971409
      MA3; MA3 domain
      pfam02854
      Location:8301058
      MIF4G; MIF4G domain
      pfam11235
      Location:202330
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      cl17013
      Location:16101656
      W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
    27. XM_047433268.1XP_047289224.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

      UniProtKB/TrEMBL
      A0A8I5KT99
    28. XM_047433267.1XP_047289223.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

      UniProtKB/TrEMBL
      A0A8I5KT99
    29. XM_047433212.1XP_047289168.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KT99
    30. XM_047433205.1XP_047289161.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KT99
    31. XM_047433201.1XP_047289157.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KT99
    32. XM_047433354.1XP_047289310.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

    33. XM_047433315.1XP_047289271.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

      UniProtKB/TrEMBL
      A0A8I5KT99
    34. XM_047433253.1XP_047289209.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KT99
    35. XM_047433279.1XP_047289235.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

      UniProtKB/TrEMBL
      A0A8I5KT99
    36. XM_047433198.1XP_047289154.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KT99
    37. XM_047433353.1XP_047289309.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

    38. XM_047433352.1XP_047289308.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

    39. XM_047433302.1XP_047289258.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

      UniProtKB/TrEMBL
      A0A8I5KT99
    40. XM_047433242.1XP_047289198.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5KT99, A0A8J9G7U8
    41. XM_047433269.1XP_047289225.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

      UniProtKB/TrEMBL
      A0A8I5KT99
    42. XM_047433266.1XP_047289222.1  eukaryotic translation initiation factor 4 gamma 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I5KT99
    43. XM_047433262.1XP_047289218.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KT99

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      20632859..21003583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339387.1XP_054195362.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

      UniProtKB/TrEMBL
      A0A8I5KT99
    2. XM_054339394.1XP_054195369.1  eukaryotic translation initiation factor 4 gamma 3 isoform X40

      UniProtKB/TrEMBL
      B4DZE1
    3. XM_054339390.1XP_054195365.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

      UniProtKB/TrEMBL
      A0A8I5KT99
    4. XM_054339357.1XP_054195332.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KT99
    5. XM_054339361.1XP_054195336.1  eukaryotic translation initiation factor 4 gamma 3 isoform X43

      UniProtKB/TrEMBL
      A0A8I5KT99
    6. XM_054339376.1XP_054195351.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

      UniProtKB/TrEMBL
      A0A8I5KT99
    7. XM_054339369.1XP_054195344.1  eukaryotic translation initiation factor 4 gamma 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I5KT99
    8. XM_054339381.1XP_054195356.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

      UniProtKB/TrEMBL
      A0A8I5KT99
    9. XM_054339365.1XP_054195340.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

      UniProtKB/TrEMBL
      A0A804HJV5, A0A8I5KT99
    10. XM_054339368.1XP_054195343.1  eukaryotic translation initiation factor 4 gamma 3 isoform X44

      UniProtKB/TrEMBL
      A0A8I5KT99, A0A8I5QJH9
    11. XM_054339366.1XP_054195341.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KT99
    12. XM_054339353.1XP_054195328.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KT99
    13. XM_054339386.1XP_054195361.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

      UniProtKB/TrEMBL
      A0A8I5KT99
    14. XM_054339389.1XP_054195364.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

      UniProtKB/TrEMBL
      A0A8I5KT99
    15. XM_054339388.1XP_054195363.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

      UniProtKB/TrEMBL
      A0A8I5KT99
    16. XM_054339379.1XP_054195354.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

      UniProtKB/TrEMBL
      A0A0A0MSA7, A0A8I5KT99
    17. XM_054339378.1XP_054195353.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

      UniProtKB/TrEMBL
      A0A8I5KT99
    18. XM_054339384.1XP_054195359.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

      UniProtKB/TrEMBL
      A0A8I5KT99
    19. XM_054339373.1XP_054195348.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

      UniProtKB/TrEMBL
      A0A8I5KT99
    20. XM_054339382.1XP_054195357.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

      UniProtKB/TrEMBL
      A0A8I5KT99
    21. XM_054339380.1XP_054195355.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

      UniProtKB/TrEMBL
      A0A8I5KT99
    22. XM_054339367.1XP_054195342.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

      UniProtKB/TrEMBL
      A0A8I5KT99
    23. XM_054339364.1XP_054195339.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

      UniProtKB/TrEMBL
      A0A804HJV5, A0A8I5KT99
    24. XM_054339377.1XP_054195352.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

      UniProtKB/TrEMBL
      A0A8I5KT99
    25. XM_054339360.1XP_054195335.1  eukaryotic translation initiation factor 4 gamma 3 isoform X43

      UniProtKB/TrEMBL
      A0A8I5KT99
    26. XM_054339375.1XP_054195350.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

      UniProtKB/TrEMBL
      A0A8I5KT99
    27. XM_054339359.1XP_054195334.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5KT99
    28. XM_054339371.1XP_054195346.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

      UniProtKB/TrEMBL
      A0A8I5KT99
    29. XM_054339370.1XP_054195345.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

      UniProtKB/TrEMBL
      A0A8I5KT99
    30. XM_054339358.1XP_054195333.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KT99
    31. XM_054339356.1XP_054195331.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KT99
    32. XM_054339355.1XP_054195330.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5KT99
    33. XM_054339393.1XP_054195368.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

    34. XM_054339385.1XP_054195360.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

      UniProtKB/TrEMBL
      A0A8I5KT99
    35. XM_054339363.1XP_054195338.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KT99
    36. XM_054339374.1XP_054195349.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

      UniProtKB/TrEMBL
      A0A8I5KT99
    37. XM_054339354.1XP_054195329.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KT99
    38. XM_054339392.1XP_054195367.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

    39. XM_054339391.1XP_054195366.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

    40. XM_054339383.1XP_054195358.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

      UniProtKB/TrEMBL
      A0A8I5KT99
    41. XM_054339362.1XP_054195337.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5KT99, A0A8J9G7U8
    42. XM_054339372.1XP_054195347.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

      UniProtKB/TrEMBL
      A0A8I5KT99
    43. XM_054339352.1XP_054195327.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KT99