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    IFS2 2-hydroxyisoflavanone synthase [ Glycine max (soybean) ]

    Gene ID: 606705, updated on 3-Feb-2025

    Summary

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    Gene symbol
    IFS2
    Gene description
    2-hydroxyisoflavanone synthase
    Locus tag
    GLYMA_13G173500v4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Glycine max
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade; NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine; Glycine subgen. Soja
    Also known as
    IFS1; CYP93C1v2
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    Genomic context

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    See IFS2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2025_01 current Glycine_max_v4.0 (GCF_000004515.6) 13 NC_038249.2 (28182456..28184534)
    103 previous assembly Glycine_max_v2.1 (GCF_000004515.5) 13 NC_038249.1 (28761503..28763581)

    Chromosome 13 - NC_038249.2Genomic Context describing neighboring genes Neighboring gene 2-hydroxyisoflavanone synthase-like Neighboring gene uncharacterized LOC100780130 Neighboring gene isoflavone 4'-O-methyltransferase Neighboring gene isoflavone 4'-O-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds. Gupta OP, et al. DNA Cell Biol, 2019 Jun. PMID 31017480
    2. Genistein production in rice seed via transformation with soybean IFS genes. Sohn SI, et al. Plant Sci, 2014 Mar. PMID 24467893
    3. RNA interference of soybean isoflavone synthase genes leads to silencing in tissues distal to the transformation site and to enhanced susceptibility to Phytophthora sojae. Subramanian S, et al. Plant Physiol, 2005 Apr. PMID 15778457, Free PMC Article
    4. Isoflavonoid biosynthesis and accumulation in developing soybean seeds. Dhaubhadel S, et al. Plant Mol Biol, 2003 Dec. PMID 15082922
    5. Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean. Steele CL, et al. Arch Biochem Biophys, 1999 Jul 1. PMID 10375412

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytosine Methylation of both isoforms of the Isoflavone Synthase Gene Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds
      Title: Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds.
    2. IFS2 is anchored in the endoplasmic reticulum and is involved in the isoflavonoid metabolon.
      Title: Twin anchors of the soybean isoflavonoid metabolon: evidence for tethering of the complex to the endoplasmic reticulum by IFS and C4H.
    3. Southern blot analysis of eight transgenic rice plants reveals that the transgenic plants have one to three copies of both the soybean IFS1 or IFS2 genes.
      Title: Genistein production in rice seed via transformation with soybean IFS genes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-hydroxyisoflavanone synthase
    Names
    Cytochrome P450 93C1v2
    cytochrome P450 monooxygenase CYP93C1v2p
    isoflavone synthase 2
    max cytochrome P450 monooxygenase CYP93C1
    NP_001238515.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001251586.2 → NP_001238515.2  2-hydroxyisoflavanone synthase

      Status: VALIDATED

      Source sequence(s)
      ACUP04004714, AK245122
      UniProtKB/Swiss-Prot
      Q9SWR5
      UniProtKB/TrEMBL
      A0A411P320, B5L5F6, K9LH71
      Conserved Domains (1) summary
      cd20655
      Location:68 → 509
      CYP93; cytochrome P450 family 93

    RefSeqs of Annotated Genomes: GCF_000004515.6-RS_2025_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Glycine_max_v4.0 Primary Assembly

    Genomic

    1. NC_038249.2 Reference Glycine_max_v4.0 Primary Assembly

      Range
      28182456..28184534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SWR5.1 GenPept UniProtKB/Swiss-Prot:Q9SWR5

    Gene LinkOut

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