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    dadX alanine racemase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945754, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dadX
    Official Full Name
    alanine racemase 2
    Primary source
    ECOCYC:EG11408
    Locus tag
    b1190
    See related
    ASAP:ABE-0003997
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    alnA; alnB; dadB; ECK1178
    Summary
    Alanine racemase 2 (DadX) catalyzes the interconversion of D- and L-alanine. [More information is available at EcoCyc: EG11408].
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    Genomic context

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    Sequence:
    NC_000913.3 (1238879..1239949)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04293 family protein YcgB Neighboring gene D-amino acid dehydrogenase Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter Neighboring gene murein tetrapeptide carboxypeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peptidoglycan biosynthesis in Escherichia coli: variations in the metabolism of alanine and D-alanyl-D-alanine. de Roubin MR, et al. J Gen Microbiol, 1992 Aug. PMID 1527514
    2. Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W. Lambert MP, et al. J Bacteriol, 1972 Jun. PMID 4555420, Free PMC Article
    3. Studies on Escherichia coli enzymes involved in the synthesis of uridine diphosphate-N-acetyl-muramyl-pentapeptide. Lugtenberg EJ. J Bacteriol, 1972 Apr. PMID 4552992, Free PMC Article
    4. Factors affecting the level of alanine racemase in Escherichia coli. Lambert MP, et al. J Bacteriol, 1972 Mar. PMID 4551748, Free PMC Article
    5. D-alanine oxidase from Escherichia coli: participation in the oxidation of L-alanine. Raunio RP, et al. J Bacteriol, 1973 Aug. PMID 4146873, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alanine racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine racemase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alanine racemase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-alanine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-alanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-alanine oxidation to pyruvate via D-alanine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in alanine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alanine racemase 2
    NP_415708.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1238879..1239949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415708.1 alanine racemase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415708.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7D7KEW7
      Conserved Domains (1) summary
      PRK03646
      Location:2 → 356
      dadX; catabolic alanine racemase
    Nucleotide Protein
    Heading Accession and Version

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