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    dsrA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946470, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dsrA
    Primary source
    ECOCYC:G7047
    Locus tag
    b1954
    See related
    ASAP:ABE-0006490
    Gene type
    ncRNA
    RNA name
    other
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1952
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    Genomic context

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    Sequence:
    NC_000913.3 (2025223..2025313, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein DsrB Neighboring gene stress-induced protein Neighboring gene putative mannosyl-3-phosphoglycerate phosphatase Neighboring gene diguanylate cyclase DgcQ Neighboring gene protein YodC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thermodynamic aspects of the self-assembly of DsrA, a small noncoding RNA from Escherichia coli. Geinguenaud F, et al. Acta Biochim Pol, 2014. PMID 24455758
    2. DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription. Majdalani N, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770508, Free PMC Article
    3. RecA-independent pathways of lambdoid prophage induction in Escherichia coli. Rozanov DV, et al. J Bacteriol, 1998 Dec. PMID 9829941, Free PMC Article
    4. Riboregulation in Escherichia coli: DsrA RNA acts by RNA:RNA interactions at multiple loci. Lease RA, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770507, Free PMC Article
    5. Evaluation of the dynamic structure of DsrA RNA from E. coli and its functional consequences. Rolle K, et al. J Biochem, 2006 Mar. PMID 16567408

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tight regulation and fine-tuning of mreB gene expression in response to cellular stresses is discussed in regard to the effect of the MreB protein on cell elongation.
      Title: Riboregulation of the bacterial actin-homolog MreB by DsrA small noncoding RNA.
    2. We report here for the first time the thermodynamic basis of DsrA small non coding RNA self-assembly.
      Title: Thermodynamic aspects of the self-assembly of DsrA, a small noncoding RNA from Escherichia coli.
    3. Study shows that DsrA.rpoS RNA duplex formation occurs in the presence of the HfqG29A mutant protein at low temperature, whereas synthesis of RpoS was greatly diminished.
      Title: Duplex formation between the sRNA DsrA and rpoS mRNA is not sufficient for efficient RpoS synthesis at low temperature.
    4. Simultaneous overexpression of noncoding small RNAs, DsrA, RprA and ArcZ, increased acid tolerance supra-additively during active cell growth, and provided protection against carboxylic acid and oxidative stress.
      Title: Synthetic tolerance: three noncoding small RNAs, DsrA, ArcZ and RprA, acting supra-additively against acid stress.
    5. The molecular envelopes of Hfq(Ec) in complex with DsrA(34) revealed an overall asymmetric shape of the complex in solution with the protein maintaining its doughnut-like structure, whereas the extended DsrA(34) is flexible and displays an ensemble of different spatial arrangements.
      Title: Structural flexibility of RNA as molecular basis for Hfq chaperone function.
    6. results indicate that DsrA modulates multidrug efflux through activation of genes encoding the MdtEF pump in E. coli
      Title: Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli.
    7. rpoS leader sequences upstream of this stem-loop greatly increase the sensitivity of rpoS mRNA to Hfq and DsrA.
      Title: The rpoS mRNA leader recruits Hfq to facilitate annealing with DsrA sRNA.
    8. the molecular function of DsrA not only facilitates ribosome loading on rpoS mRNA, but additionally involves an alternative processing of the target
      Title: Translational activation by the noncoding RNA DsrA involves alternative RNase III processing in the rpoS 5'-leader.
    9. the mutants' DsrA-dependent activation of rpoS, and their ability to stabilize DsrA noncoding RNAs against degradation in vivo
      Title: Escherichia coli Hfq has distinct interaction surfaces for DsrA, rpoS and poly(A) RNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

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