U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mltA membrane-bound lytic murein transglycosylase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944964, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mltA
    Official Full Name
    membrane-bound lytic murein transglycosylase A
    Primary source
    ECOCYC:G7457
    Locus tag
    b2813
    See related
    ASAP:ABE-0009228
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2809; mlt; ygdM
    Summary
    MltA cleaves the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG13085]. MltA is one of six (along with MltB, MltC, MltD, EmtA, and Slt70) major lytic endotransglycosylases expressed in Escherichia coli. [More information is available at EcoCyc: G7457].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2946081..2947178, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cysteine sulfinate desulfinase Neighboring gene sulfur acceptor protein CsdE Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene tRNA-Met Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage. van Straaten KE, et al. J Biol Chem, 2007 Jul 20. PMID 17502382
    2. Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin. Hussain M, et al. J Biol Chem, 1980 Apr 25. PMID 6988430
    3. Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding. Powell AJ, et al. J Mol Biol, 2006 May 26. PMID 16618494
    4. Purification and properties of a membrane-bound lytic transglycosylase from Escherichia coli. Ursinus A, et al. J Bacteriol, 1994 Jan. PMID 8288527, Free PMC Article
    5. Escherichia coli MltA: MAD phasing and refinement of a tetartohedrally twinned protein crystal structure. Barends TR, et al. Acta Crystallogr D Biol Crystallogr, 2005 May. PMID 15858272

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystallographic analysis of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose
      Title: Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage.
    2. The crystal structure of the lytic transglycosylase MltA from Escherichia coli without a membrane anchor was solved at 2.0A resolution.
      Title: Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold.
    3. Results describe the crystal structures of MltA from Neisseria gonorrhoeae and Escherichia coli.
      Title: Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic transglycosylase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables lytic transglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lytic transglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidoglycan metabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in peptidoglycan turnover IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    membrane-bound lytic murein transglycosylase A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2946081..2947178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417293.1 membrane-bound lytic murein transglycosylase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417293.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3R0MT56, A0A8T5YBU5
      Conserved Domains (1) summary
      PRK11162
      Location:1 → 354
      mltA; murein transglycosylase A; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.