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    rpiB allose-6-phosphate isomerase/ribose-5-phosphate isomerase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948602, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rpiB
    Official Full Name
    allose-6-phosphate isomerase/ribose-5-phosphate isomerase B
    Primary source
    ECOCYC:EG11827
    Locus tag
    b4090
    See related
    ASAP:ABE-0013405
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    alsI; ECK4083; yjcA
    Summary
    There are two physically and genetically distinct ribose-5-phosphate isomerases present in Escherichia coli . [More information is available at EcoCyc: EG11827].
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    Genomic context

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    Sequence:
    NC_000913.3 (4313350..4313799)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-allose ABC transporter periplasmic binding protein Neighboring gene DNA-binding transcriptional repressor AlsR Neighboring gene protein YjdP Neighboring gene 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic studies on ribose 5-phosphate isomerase mutants of Escherichia coli K-12. Skinner AJ, et al. J Bacteriol, 1974 Jun. PMID 4598000, Free PMC Article
    2. Regulation of ribose metabolism in Escherichia coli. II. Evidence for two ribose-5-phosphate isomerase activities. David J, et al. Biochim Biophys Acta, 1970 Apr 14. PMID 4909663
    3. The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction. Zhang RG, et al. J Mol Biol, 2003 Oct 3. PMID 14499611, Free PMC Article
    4. Two ribose-5-phosphate isomerases from Escherichia coli K12: partial characterisation of the enzymes and consideration of their possible physiological roles. Essenberg MK, et al. Eur J Biochem, 1975 Jul 1. PMID 1104357
    5. The regulation of ribose-5-phosphate isomerisation in Escherichia coli K12. Skinner AJ, et al. FEBS Lett, 1971 Jan 30. PMID 11945603

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data describe kinetic studies examining the allose-6-phosphate isomerase activity of RpiB from Mycobacterium tuberculosis and Escherichia coli, and show that only the E. coli enzyme can catalyze the reaction efficiently.
      Title: D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-allose 6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-allose 6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-allose 6-phosphate isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables intramolecular oxidoreductase activity, interconverting aldoses and ketoses IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribose-5-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose-5-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose-5-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose-5-phosphate isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-allose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-allose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    allose-6-phosphate isomerase/ribose-5-phosphate isomerase B
    NP_418514.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4313350..4313799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418514.1 allose-6-phosphate isomerase/ribose-5-phosphate isomerase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418514.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377B746
      Conserved Domains (1) summary
      TIGR01120
      Location:3 → 145
      rpiB; ribose 5-phosphate isomerase B
    Nucleotide Protein
    Heading Accession and Version

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