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    etk protein-tyrosine kinase Etk [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947409, updated on 3-Dec-2024

    Summary

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    Official Symbol
    etk
    Official Full Name
    protein-tyrosine kinase Etk
    Primary source
    ECOCYC:EG11826
    Locus tag
    b0981
    See related
    ASAP:ABE-0003309
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0972; yccC
    Summary
    Function characterized in enteropathogenic Escherichia coli (EPEC). [More information is available at EcoGene: EG11826]. Etk is a protein tyrosine kinase of the inner membrane that autophosphorylates and can be dephosphorylated by Etp . [More information is available at EcoCyc: EG11826].
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    Genomic context

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    Sequence:
    NC_000913.3 (1042030..1044210, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bd-II accessory subunit AppX Neighboring gene periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase Neighboring gene phosphotyrosine-protein phosphatase Etp Neighboring gene putative exopolysaccharide export lipoprotein GfcE Neighboring gene putative lipoprotein GfcD Neighboring gene capsule biosynthesis GfcC family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism. Lee DC, et al. EMBO J, 2008 Jun 18. PMID 18497741, Free PMC Article
    2. Tyrosine phosphorylation: an emerging regulatory device of bacterial physiology. Grangeasse C, et al. Trends Biochem Sci, 2007 Feb. PMID 17208443
    3. Protein tyrosine kinases in bacterial pathogens are associated with virulence and production of exopolysaccharide. Ilan O, et al. EMBO J, 1999 Jun 15. PMID 10369665, Free PMC Article
    4. New insights into the activation of Escherichia coli tyrosine kinase revealed by molecular dynamics simulation and biochemical analysis. Lu T, et al. Biochemistry, 2009 Aug 25. PMID 19634880
    5. A novel role for protein-tyrosine kinase Etk from Escherichia coli K-12 related to polymyxin resistance. Lacour S, et al. Res Microbiol, 2006 Sep. PMID 16814990

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The proposed activation mechanism of Etk involves unblocking of the enzyme's blocked active site by the flipping of the phosphorylated tyrosine574 side chain.
      Title: New insights into the activation of Escherichia coli tyrosine kinase revealed by molecular dynamics simulation and biochemical analysis.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Protein tyrosine kinases in bacterial pathogens are associated with virulence and production of exopolysaccharide.
    3. results showed that protein-kinase Wzc is not essential for polymyxin resistance, whereas protein-kinase Etk appears to play a key role in such antibiotic resistance
      Title: A novel role for protein-tyrosine kinase Etk from Escherichia coli K-12 related to polymyxin resistance.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine kinase Etk

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1042030..1044210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415501.1 protein-tyrosine kinase Etk [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415501.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828PD17
      Conserved Domains (1) summary
      PRK09841
      Location:1 → 726
      PRK09841; tyrosine-protein kinase
    Nucleotide Protein
    Heading Accession and Version

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