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    lplT lysophospholipid transporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947317, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lplT
    Official Full Name
    lysophospholipid transporter
    Primary source
    ECOCYC:EG12455
    Locus tag
    b2835
    See related
    ASAP:ABE-0009300
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2831; ygeD
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12455]. LplT is a major facilitator superfamily (MFS) protein that acts as a flippase for transbilayer movement of lysophospholipids. [More information is available at EcoCyc: EG12455].
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    Genomic context

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    Sequence:
    NC_000913.3 (2972669..2973862, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF903 domain-containing lipoprotein YgdR Neighboring gene putative NADP(H)-dependent aldo-keto reductase Tas Neighboring gene fused 2-acylglycerophospho-ethanolamine acyltransferase/acyl-acyl carrier protein synthetase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. Lin Y, et al. J Biol Chem, 2016 Jan 29. PMID 26613781, Free PMC Article
    2. Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily. Harvat EM, et al. J Biol Chem, 2005 Mar 25. PMID 15661733
    3. Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope. Niu W, et al. J Biol Chem, 2024 Sep. PMID 39173951, Free PMC Article
    4. Sequence and function of the aas gene in Escherichia coli. Jackowski S, et al. J Biol Chem, 1994 Jan 28. PMID 8300626
    5. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope.
      Title: Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope.
    2. lyso-PE and lysophosphatidylglycerol, but not lysophosphatidylcholine, are taken up by LplT for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on the inner leaflet of the membrane
      Title: Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipid:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycerophospholipid metabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within glycerophospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysophospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid translocation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysophospholipid transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2972669..2973862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417312.1 lysophospholipid transporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417312.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A778NDN6
      Conserved Domains (1) summary
      PRK11195
      Location:12 → 397
      PRK11195; lysophospholipid transporter LplT; Provisional
    Nucleotide Protein
    Heading Accession and Version

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