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    Tmem198 transmembrane protein 198 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem198provided by RGD
    Official Full Name
    transmembrane protein 198provided by RGD
    Primary source
    RGD:2319152
    See related
    EnsemblRapid:ENSRNOG00000020061 AllianceGenome:RGD:2319152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasmic vesicle and plasma membrane. Orthologous to human TMEM198 (transmembrane protein 198). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 62.6), Adrenal (RPKM 13.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem198 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84416741..84422759)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76968079..76974131)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82673959..82680151)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit family member 4 Neighboring gene uncharacterized LOC134480596 Neighboring gene chondroitin polymerizing factor Neighboring gene obscurin like cytoskeletal adaptor 1 Neighboring gene inhibin subunit alpha Neighboring gene serine/threonine kinase 11 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Liang J, et al. Mol Cell Biol, 2011 Jul. PMID 21536646, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 198

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433363.1 → NP_001420292.1  transmembrane protein 198 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JW38, D3ZHB8

    2. NM_001433364.1 → NP_001420293.1  transmembrane protein 198 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    3. NM_001433365.1 → NP_001420294.1  transmembrane protein 198 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    4. NM_001433366.1 → NP_001420295.1  transmembrane protein 198 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84416741..84422759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002730042.7 → XP_002730088.1  transmembrane protein 198 isoform X1

      Related
      ENSRNOP00000027208.3, ENSRNOT00000027208.7
      Conserved Domains (1) summary
      pfam13886
      Location:40 → 236
      DUF4203; Domain of unknown function (DUF4203)

    2. XM_039084658.2 → XP_038940586.1  transmembrane protein 198 isoform X2

      Conserved Domains (1) summary
      pfam13886
      Location:15 → 196
      DUF4203; Domain of unknown function (DUF4203)

    3. XM_063268162.1 → XP_063124232.1  transmembrane protein 198 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials