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    Rab34 RAB34, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19376, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab34provided by MGI
    Official Full Name
    RAB34, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:104606
    See related
    Ensembl:ENSMUSG00000002059 AllianceGenome:MGI:104606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rah; Narr; Rah1
    Summary
    Enables GTPase activity and guanyl nucleotide binding activity. Involved in several processes, including Golgi to plasma membrane protein transport; organelle assembly; and positive regulation of protein localization to phagocytic vesicle. Acts upstream of or within endocytosis. Located in Golgi apparatus; endosome; and ruffle. Colocalizes with phagocytic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XX. Orthologous to human RAB34 (RAB34, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 68.8), ovary adult (RPKM 45.7) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab34 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78079253..78083019)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78188427..78192193)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5250 Neighboring gene small nucleolar RNA, C/D box 4A Neighboring gene ribosomal protein L23A Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene Rab34 Hedgehog-responsive enhancer Neighboring gene protein interacting with cyclin A1 Neighboring gene SPT6, histone chaperone and transcription elongation factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78029402-78029555

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl nucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi to plasma membrane protein transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytosolic ciliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lysosomal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagosome-lysosome fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagosome-lysosome fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to phagocytic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-34
    Names
    RAB34, member of RAS oncogene family
    rab-39
    ras-related homolog
    ras-related protein Rab-39
    ras-related protein Rah

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159482.1NP_001152954.1  ras-related protein Rab-34

      See identical proteins and their annotated locations for NP_001152954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA041780, AB082927, AF327929, AV142766, BY317641
      Consensus CDS
      CCDS25094.1
      UniProtKB/Swiss-Prot
      Q64008, Q8BHJ0, Q99P59, Q99P90
      UniProtKB/TrEMBL
      Q0PD20
      Related
      ENSMUSP00000002128.8, ENSMUST00000002128.14
      Conserved Domains (2) summary
      smart00175
      Location:54213
      RAB; Rab subfamily of small GTPases
      cd04108
      Location:53220
      Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)
    2. NM_033475.3NP_258436.2  ras-related protein Rab-34

      See identical proteins and their annotated locations for NP_258436.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB082927, AV142766, BB643883, BY195955, BY234941
      Consensus CDS
      CCDS25094.1
      UniProtKB/Swiss-Prot
      Q64008, Q8BHJ0, Q99P59, Q99P90
      UniProtKB/TrEMBL
      Q0PD20
      Related
      ENSMUSP00000103958.3, ENSMUST00000108322.9
      Conserved Domains (2) summary
      smart00175
      Location:54213
      RAB; Rab subfamily of small GTPases
      cd04108
      Location:53220
      Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78079253..78083019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)