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    Tbxas1 thromboxane A synthase 1, platelet [ Mus musculus (house mouse) ]

    Gene ID: 21391, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tbxas1provided by MGI
    Official Full Name
    thromboxane A synthase 1, plateletprovided by MGI
    Primary source
    MGI:MGI:98497
    See related
    Ensembl:ENSMUSG00000029925 AllianceGenome:MGI:98497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TS; TXS; CYP5; THAS; TXAS; CYP5A1
    Summary
    Enables thromboxane-A synthase activity. Predicted to be involved in intracellular chloride ion homeostasis; positive regulation of vasoconstriction; and prostaglandin biosynthetic process. Predicted to be located in cytosol and endoplasmic reticulum membrane. Is expressed in several structures, including bone marrow; brain; liver; lung; and metanephros. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome and cerebral infarction. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 4.2), spleen adult (RPKM 3.2) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tbxas1 in Genome Data Viewer
    Location:
    6 B1; 6 17.85 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38817897..39061524)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38864159..39084590)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:38676623-38676923 Neighboring gene STARR-positive B cell enhancer mm9_chr6:38677325-38677625 Neighboring gene RIKEN cDNA 4930502C15 gene Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene predicted gene, 53285 Neighboring gene Hipk2R16 erythroid cis-regulatory module Neighboring gene predicted gene, 33767 Neighboring gene predicted gene, 57771 Neighboring gene predicted gene, 52859 Neighboring gene predicted gene, 23010 Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene predicted gene, 46989 Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene STARR-seq mESC enhancer starr_15629 Neighboring gene lysine (K)-specific demethylase 7A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 12-hydroxyheptadecatrienoic acid synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hydroperoxy icosatetraenoate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydroperoxy icosatetraenoate dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    enables thromboxane-A synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thromboxane-A synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thromboxane-A synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in icosanoid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular chloride ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    thromboxane-A synthase
    Names
    TXA synthase
    cytochrome P450 5A1
    hydroperoxy icosatetraenoate dehydratase
    thromboxane synthase
    NP_001397404.1
    NP_001397405.1
    NP_001397406.1
    NP_035669.3
    XP_006505939.1
    XP_006505942.1
    XP_006505943.1
    XP_006505944.1
    XP_011239582.1
    XP_017176988.1
    XP_017176989.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410475.1NP_001397404.1  thromboxane-A synthase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016
      UniProtKB/TrEMBL
      Q8K320
    2. NM_001410476.1NP_001397405.1  thromboxane-A synthase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016
      UniProtKB/TrEMBL
      Q3UTF0
    3. NM_001410477.1NP_001397406.1  thromboxane-A synthase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016
      UniProtKB/TrEMBL
      Q3UTF0
    4. NM_011539.4NP_035669.3  thromboxane-A synthase isoform 1

      See identical proteins and their annotated locations for NP_035669.3

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016
      Consensus CDS
      CCDS20018.1
      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Related
      ENSMUSP00000003017.7, ENSMUST00000003017.13
      Conserved Domains (1) summary
      pfam00067
      Location:47528
      p450; Cytochrome P450

    RNA

    1. NR_177077.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125327, AC154016

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      38817897..39061524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321499.3XP_017176988.1  thromboxane-A synthase isoform X1

      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47528
      p450; Cytochrome P450
    2. XM_017321500.3XP_017176989.1  thromboxane-A synthase isoform X1

      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47528
      p450; Cytochrome P450
    3. XM_011241280.4XP_011239582.1  thromboxane-A synthase isoform X1

      See identical proteins and their annotated locations for XP_011239582.1

      UniProtKB/Swiss-Prot
      P36423, P97505
      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47528
      p450; Cytochrome P450
    4. XM_006505881.4XP_006505944.1  thromboxane-A synthase isoform X7

      UniProtKB/TrEMBL
      Q3UTF0
      Conserved Domains (1) summary
      cl12078
      Location:47378
      p450; Cytochrome P450
    5. XM_006505879.5XP_006505942.1  thromboxane-A synthase isoform X5

      UniProtKB/TrEMBL
      Q3UTF0
      Conserved Domains (1) summary
      cl12078
      Location:47455
      p450; Cytochrome P450
    6. XM_006505876.4XP_006505939.1  thromboxane-A synthase isoform X2

      UniProtKB/TrEMBL
      Q8K320
      Conserved Domains (1) summary
      pfam00067
      Location:47528
      p450; Cytochrome P450
    7. XM_006505880.5XP_006505943.1  thromboxane-A synthase isoform X6

      Conserved Domains (1) summary
      pfam00067
      Location:6410
      p450; Cytochrome P450