Cetn3 centrin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cetn3provided by MGI
Official Full Name: centrin 3provided by MGI
Primary source: MGI:MGI:1097706
See related: Ensembl:ENSMUSG00000021537 AllianceGenome:MGI:1097706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MmCEN3
Summary: Enables G-protein beta/gamma-subunit complex binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Located in centriole; ciliary basal body; and photoreceptor connecting cilium. Is expressed in several structures, including foregut; musculoskeletal system; nervous system; sensory organ; and submandibular gland primordium. Orthologous to human CETN3 (centrin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 18.1), CNS E11.5 (RPKM 17.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 43.68 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (81928201..81945274)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (81780636..81797155)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22).
Title: Deletion of both centrin 2 (CETN2) and CETN3 destabilizes the distal connecting cilium of mouse photoreceptors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary transition zone	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore nuclear basket	ISO Inferred from Sequence Orthology more info
part_of nuclear pore nuclear basket	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
part_of transcription export complex 2	ISO Inferred from Sequence Orthology more info
part_of transcription export complex 2	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: centrin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007684.4 → NP_031710.1 centrin-3

See identical proteins and their annotated locations for NP_031710.1

Status: VALIDATED

Source sequence(s)

AI851499, AK006891, BY103593

Consensus CDS

CCDS26663.1

UniProtKB/Swiss-Prot

O35648

UniProtKB/TrEMBL

Q545L8, Q9CYN1, Q9D046

Related

ENSMUSP00000022009.9, ENSMUST00000022009.10

Conserved Domains (1) summary

PTZ00183
Location:15 → 166

PTZ00183; centrin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

81928201..81945274

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517074.5 → XP_006517137.1 centrin-3 isoform X1

UniProtKB/TrEMBL

Q9CYN1

Conserved Domains (1) summary

PTZ00183
Location:15 → 157

PTZ00183; centrin; Provisional