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    Clk3 CDC-like kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 102414, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Clk3provided by MGI
    Official Full Name
    CDC-like kinase 3provided by MGI
    Primary source
    MGI:MGI:1098670
    See related
    Ensembl:ENSMUSG00000032316 AllianceGenome:MGI:1098670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Located in nucleus. Is expressed in several structures, including cerebral cortex; craniocervical region bone; ganglia; neural retina; and thyroid gland. Orthologous to human CLK3 (CDC like kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 73.1), liver E14.5 (RPKM 33.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clk3 in Genome Data Viewer
    Location:
    9 B; 9 31.47 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57657904..57672397, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57750621..57766235, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Cyp1a2 5' enhancer Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene Cyp1a1 5' regulatory region Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 1 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene STARR-positive B cell enhancer ABC_E11409 Neighboring gene CapStarr-seq enhancers MGSCv37_chr9:57617333-57617516 and MGSCv37_chr9:57617555-57617846 Neighboring gene predicted gene, 32510 Neighboring gene AT-rich interaction domain 3B Neighboring gene STARR-seq mESC enhancer starr_24247 Neighboring gene STARR-positive B cell enhancer ABC_E2889 Neighboring gene STARR-positive B cell enhancer ABC_E6741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3. Xue M, et al. Cancer Med, 2023 Apr. PMID 36583532, Free PMC Article
    2. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. Ma X, et al. In Vitro Cell Dev Biol Anim, 2024 Apr. PMID 38438604
    3. Differential gene expression in CD3epsilon- and RAG1-deficient thymuses: definition of a set of genes potentially involved in thymocyte maturation. Carrier A, et al. Immunogenetics, 1999 Dec. PMID 10630289
    4. Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Nayler O, et al. Biochem J, 1997 Sep 15. PMID 9307018, Free PMC Article
    5. Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Zhou J, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Dec. PMID 29055695

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
      Title: CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
    2. MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
      Title: MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36552, MGC103028

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase CLK3
    Names
    cdc2/CDC28-like protein kinase 3
    NP_001397105.1
    NP_001397106.1
    NP_001397107.1
    NP_001397108.1
    NP_001397109.1
    NP_001397110.1
    NP_001397111.1
    NP_031739.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410176.1 → NP_001397105.1  dual specificity protein kinase CLK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      UniProtKB/Swiss-Prot
      O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
      UniProtKB/TrEMBL
      A0A8Z1S2G3

    2. NM_001410177.1 → NP_001397106.1  dual specificity protein kinase CLK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      UniProtKB/Swiss-Prot
      O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
      UniProtKB/TrEMBL
      A0A8Z1S2G3

    3. NM_001410178.1 → NP_001397107.1  dual specificity protein kinase CLK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      UniProtKB/Swiss-Prot
      O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
      UniProtKB/TrEMBL
      A0A8Z1S2G3

    4. NM_001410179.1 → NP_001397108.1  dual specificity protein kinase CLK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      UniProtKB/Swiss-Prot
      O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
      UniProtKB/TrEMBL
      A0A8Z1S2G3

    5. NM_001410180.1 → NP_001397109.1  dual specificity protein kinase CLK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      UniProtKB/Swiss-Prot
      O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
      UniProtKB/TrEMBL
      A0A8Z1S2G3

    6. NM_001410181.1 → NP_001397110.1  dual specificity protein kinase CLK3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122515

    7. NM_001410182.1 → NP_001397111.1  dual specificity protein kinase CLK3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122515

    8. NM_007713.5 → NP_031739.4  dual specificity protein kinase CLK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      Consensus CDS
      CCDS23232.1
      UniProtKB/Swiss-Prot
      O35492, Q3TJU0, Q3UIF5, Q3V463, Q5U4I1, Q8C1V1
      UniProtKB/TrEMBL
      A0A1L1SST3, A0A8Z1S2G3
      Related
      ENSMUSP00000067341.8, ENSMUST00000065330.8
      Conserved Domains (1) summary
      cd14214
      Location:142 → 472
      PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57657904..57672397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35492.3 GenPept UniProtKB/Swiss-Prot:O35492

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