Creb3l4 cAMP responsive element binding protein 3-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Creb3l4provided by MGI
Official Full Name: cAMP responsive element binding protein 3-like 4provided by MGI
Primary source: MGI:MGI:1916603
See related: Ensembl:ENSMUSG00000027938 AllianceGenome:MGI:1916603
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JAL; CREB4; acre1; AIBZIP; TISP40; 1700012K17Rik; 5330432F22Rik
Summary: This gene encodes a CREB (cyclic AMP-responsive element-binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein may play a role in adiposity and male germ cell development. Homozygous knockout mice for this gene show increased adipogenesis, elevated testicular germ cell apoptosis and defects in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Biased expression in testis adult (RPKM 127.4), colon adult (RPKM 11.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.21 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90144805..90161387, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90237498..90244582, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tisp40 prevents cardiac ischemia/reperfusion injury through the hexosamine biosynthetic pathway in male mice.
Title: Tisp40 prevents cardiac ischemia/reperfusion injury through the hexosamine biosynthetic pathway in male mice.
Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury.
Title: Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury.
Tisp40 aggravates tubular cells apoptosis in renal ischemia reperfusion injury.
Title: Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells.
these findings suggest that Tisp40 plays a critical role in the TGF-beta/ Smads pathway involved in this process. Hence, Tisp40 could be a useful therapeutic target in the fight against renal tubulointerstitial fibrosis
Title: Identification of Tisp40 as an Essential Regulator of Renal Tubulointerstitial Fibrosis via TGF-β/Smads Pathway.
Creb3l4 is an essential negative regulator of adipogenesis.
Title: Identification of Creb3l4 as an essential negative regulator of adipogenesis.
Disruption of TISP40 caused ER stress and activation of caspase 12 but not caspase 9, leading to apoptosis of meiotic/postmeiotic germ cells.
Title: The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis.
we show that Atce1/Tisp40alpha is the major form of CREB3L4 in mouse testis. These findings suggest that testis-specific isoforms of Creb3l4 could play an important role in spermatid differentiation.
Title: Stage-specific expression of the Atce1/Tisp40alpha isoform of CREB3L4 in mouse spermatids.
Tisp40 and CREM bind to the Tisp40 promoter in vivo
Title: Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation.
Creb3l4 plays a role in male germ cell development
Title: Reduction of spermatogenesis but not fertility in Creb3l4-deficient mice.
TISP40 functions by binding to the unfolded protein response element via the Rip pathway.
Title: Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV258827 (e-PCR)
- UniSTS:164213

Creb3l4 (e-PCR), detects polymorphism
- UniSTS:547202

AV040530 (e-PCR)
- UniSTS:178889

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in inner acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclic AMP-responsive element-binding protein 3-like protein 4

Names: androgen-induced basic leucine zipper; attaching to CRE-like 1; cAMP-responsive element-binding protein 3-like protein 4; transcript induced in spermiogenesis protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001307934.1 → NP_001294863.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

See identical proteins and their annotated locations for NP_001294863.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1, also known as Tisp40beta or CREB3L4beta).

Source sequence(s)

AB052779, AC119825, BB026279

Consensus CDS

CCDS17524.1

UniProtKB/Swiss-Prot

Q9D2A5, Q9DAE0

Related

ENSMUSP00000102992.2, ENSMUST00000107369.2

Conserved Domains (1) summary

cd14689
Location:194 → 254

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
NM_001307935.1 → NP_001294864.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

See identical proteins and their annotated locations for NP_001294864.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate 5' exons and has a 5' end that extends into an intron compared to variant 1. This results in a distinct 5' UTR and the use of a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as Atce1/Tisp40alpha or CREB3L4alpha) is shorter and lacks the N-terminal transcriptional activation domain compared to isoform 1 (PMID: 15938716).

Source sequence(s)

AC119825, AK005918, AK019928, BB026279

UniProtKB/Swiss-Prot

Q9D2A5

Conserved Domains (2) summary

COG0675
Location:129 → 213

InsQ; Transposase [Mobilome: prophages, transposons]

cd14689
Location:139 → 199

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
NM_030080.3 → NP_084356.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

See identical proteins and their annotated locations for NP_084356.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1, also known as Tisp40beta or CREB3L4beta).

Source sequence(s)

AK019928, BB026279

Consensus CDS

CCDS17524.1

UniProtKB/Swiss-Prot

Q9D2A5, Q9DAE0

Related

ENSMUSP00000029547.4, ENSMUST00000029547.10

Conserved Domains (1) summary

cd14689
Location:194 → 254

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90144805..90161387 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502310.5 → XP_006502373.5 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

Conserved Domains (1) summary

cd14689
Location:269 → 329

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_006502311.5 → XP_006502374.4 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

Conserved Domains (1) summary

cd14689
Location:239 → 299

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_006502315.5 → XP_006502378.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4

See identical proteins and their annotated locations for XP_006502378.1

Conserved Domains (1) summary

cd14689
Location:72 → 132

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_006502314.5 → XP_006502377.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4

See identical proteins and their annotated locations for XP_006502377.1

Conserved Domains (1) summary

cd14689
Location:72 → 132

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_036163411.1 → XP_036019304.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3

UniProtKB/Swiss-Prot

Q9D2A5, Q9DAE0

Conserved Domains (1) summary

cd14689
Location:194 → 254

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_017319808.3 → XP_017175297.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3

UniProtKB/Swiss-Prot

Q9D2A5, Q9DAE0

Conserved Domains (1) summary

cd14689
Location:194 → 254

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain