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    Enah ENAH actin regulator [ Mus musculus (house mouse) ]

    Gene ID: 13800, updated on 27-Nov-2024

    Summary

    Official Symbol
    Enahprovided by MGI
    Official Full Name
    ENAH actin regulatorprovided by MGI
    Primary source
    MGI:MGI:108360
    See related
    Ensembl:ENSMUSG00000022995 AllianceGenome:MGI:108360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mena; WBP8; Ndpp1; NDPP-1
    Summary
    Enables SH3 domain binding activity and profilin binding activity. Involved in actin filament organization and actin polymerization-dependent cell motility. Acts upstream of or within actin polymerization or depolymerization; cellular response to leukemia inhibitory factor; and nervous system development. Located in several cellular components, including focal adhesion; lamellipodium; and stress fiber. Is expressed in several structures, including brain; early embryo; embryo ectoderm; gonad; and limb bud. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.7), CNS E14 (RPKM 9.8) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Enah in Genome Data Viewer
    Location:
    1 H5; 1 84.93 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (181723949..181848132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181896384..182027556, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3345 Neighboring gene STARR-seq mESC enhancer starr_03245 Neighboring gene predicted gene 5533 Neighboring gene STARR-positive B cell enhancer ABC_E10070 Neighboring gene predicted gene, 33669 Neighboring gene STARR-seq mESC enhancer starr_03248 Neighboring gene STARR-seq mESC enhancer starr_03253 Neighboring gene STARR-seq mESC enhancer starr_03255 Neighboring gene STARR-seq mESC enhancer starr_03256 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene STARR-seq mESC enhancer starr_03257 Neighboring gene STARR-seq mESC enhancer starr_03259 Neighboring gene STARR-seq mESC enhancer starr_03262 Neighboring gene predicted gene, 38648 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GCT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables profilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables profilin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein enabled homolog
    Names
    NPC derived proline rich protein 1
    enabled homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083120.3NP_001076589.1  protein enabled homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122204, AC165229
      Consensus CDS
      CCDS48473.1
      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      UniProtKB/TrEMBL
      A0A0A6YW06
      Related
      ENSMUSP00000141344.2, ENSMUST00000195059.6
      Conserved Domains (2) summary
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:748781
      VASP_tetra; VASP tetramerization domain
    2. NM_001083121.3NP_001076590.1  protein enabled homolog isoform 4

      See identical proteins and their annotated locations for NP_001076590.1

      Status: VALIDATED

      Source sequence(s)
      AC122204, AC165229
      Consensus CDS
      CCDS78764.1
      UniProtKB/TrEMBL
      A0A0A6YXC8
      Related
      ENSMUSP00000141462.2, ENSMUST00000193703.6
      Conserved Domains (2) summary
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:504537
      VASP_tetra; VASP tetramerization domain
    3. NM_008680.4NP_032706.2  protein enabled homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122204, AC165229
      Consensus CDS
      CCDS48474.1
      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      UniProtKB/TrEMBL
      E9QKQ9
      Related
      ENSMUSP00000106659.4, ENSMUST00000111030.6
      Conserved Domains (2) summary
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:752785
      VASP_tetra; VASP tetramerization domain
    4. NM_010135.4NP_034265.2  protein enabled homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122204, AC165229
      Consensus CDS
      CCDS35811.1
      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      UniProtKB/TrEMBL
      E9QLZ9
      Related
      ENSMUSP00000077781.7, ENSMUST00000078719.13
      Conserved Domains (2) summary
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:767800
      VASP_tetra; VASP tetramerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      181723949..181848132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159237.1XP_036015130.1  protein enabled homolog isoform X19

      UniProtKB/TrEMBL
      A0A0A6YXC8, E9QKR1
      Related
      ENSMUSP00000106653.5, ENSMUST00000111024.10
      Conserved Domains (3) summary
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:525559
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:356382
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
    2. XM_006496652.4XP_006496715.1  protein enabled homolog isoform X20

      UniProtKB/TrEMBL
      A0A0A6YXC8
      Related
      ENSMUSP00000141936.2, ENSMUST00000193074.6
      Conserved Domains (2) summary
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:498532
      VASP_tetra; VASP tetramerisation domain
    3. XM_006496651.5XP_006496714.1  protein enabled homolog isoform X18

      UniProtKB/TrEMBL
      A0A0A6YXC8
      Conserved Domains (2) summary
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:535569
      VASP_tetra; VASP tetramerisation domain
    4. XM_006496650.4XP_006496713.1  protein enabled homolog isoform X15

      UniProtKB/TrEMBL
      A0A0A6YXC8
      Conserved Domains (2) summary
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:556590
      VASP_tetra; VASP tetramerisation domain
    5. XM_006496646.5XP_006496709.1  protein enabled homolog isoform X8

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:333553
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:779813
      VASP_tetra; VASP tetramerisation domain
    6. XM_030247170.2XP_030103030.1  protein enabled homolog isoform X4

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:333553
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:800834
      VASP_tetra; VASP tetramerisation domain
    7. XM_030247143.2XP_030103003.1  protein enabled homolog isoform X2

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:352572
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:819853
      VASP_tetra; VASP tetramerisation domain
    8. XM_030247134.2XP_030102994.1  protein enabled homolog isoform X1

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:356576
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:823857
      VASP_tetra; VASP tetramerisation domain
    9. XM_030247158.2XP_030103018.1  protein enabled homolog isoform X3

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:337557
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:804838
      VASP_tetra; VASP tetramerisation domain
    10. XM_006496645.5XP_006496708.1  protein enabled homolog isoform X7

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:337557
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:783817
      VASP_tetra; VASP tetramerisation domain
    11. XM_036159112.1XP_036015005.1  protein enabled homolog isoform X13

      UniProtKB/TrEMBL
      A0A0A6YXC8
      Conserved Domains (3) summary
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:575609
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:406432
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
    12. XM_006496643.5XP_006496706.1  protein enabled homolog isoform X5

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:352572
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:798832
      VASP_tetra; VASP tetramerisation domain
    13. XM_036159177.1XP_036015070.1  protein enabled homolog isoform X16

      UniProtKB/TrEMBL
      A0A0A6YXC8
      Conserved Domains (3) summary
      cd01207
      Location:36143
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:554588
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:406432
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
    14. XM_006496648.4XP_006496711.1  protein enabled homolog isoform X11

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (2) summary
      PHA03247
      Location:231451
      PHA03247; large tegument protein UL36; Provisional
      pfam08776
      Location:698732
      VASP_tetra; VASP tetramerisation domain
    15. XM_006496649.5XP_006496712.1  protein enabled homolog isoform X12

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (2) summary
      PHA03247
      Location:227447
      PHA03247; large tegument protein UL36; Provisional
      pfam08776
      Location:694728
      VASP_tetra; VASP tetramerisation domain
    16. XM_036159132.1XP_036015025.1  protein enabled homolog isoform X14

      UniProtKB/TrEMBL
      A0A0A6YXC8
      Conserved Domains (3) summary
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:568602
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:420446
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
    17. XM_006496647.5XP_006496710.1  protein enabled homolog isoform X10

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:302522
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:769803
      VASP_tetra; VASP tetramerisation domain
    18. XM_036159054.1XP_036014947.1  protein enabled homolog isoform X9

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (4) summary
      PHA03247
      Location:306526
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:773807
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:604630
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
    19. XM_036159202.1XP_036015095.1  protein enabled homolog isoform X17

      UniProtKB/TrEMBL
      A0A0A6YXC8
      Conserved Domains (3) summary
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:544578
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:375401
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
    20. XM_006496644.5XP_006496707.1  protein enabled homolog isoform X6

      UniProtKB/Swiss-Prot
      P70430, P70431, P70432, P70433, Q03173, Q5D053
      Conserved Domains (3) summary
      PHA03247
      Location:325545
      PHA03247; large tegument protein UL36; Provisional
      cd01207
      Location:5112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:792826
      VASP_tetra; VASP tetramerisation domain