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    Bcl2l12 BCL2 like 12 [ Mus musculus (house mouse) ]

    Gene ID: 75736, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bcl2l12provided by MGI
    Official Full Name
    BCL2 like 12provided by MGI
    Primary source
    MGI:MGI:1922986
    See related
    Ensembl:ENSMUSG00000003190 AllianceGenome:MGI:1922986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcl-L12; Bcl2-L12; 2810475P17Rik; 5430429M05Rik
    Summary
    Enables p53 binding activity. Acts upstream of or within negative regulation of cellular senescence and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; quadriceps femoris muscle; and respiratory system. Orthologous to human BCL2L12 (BCL2 like 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 30.0), limb E14.5 (RPKM 23.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcl2l12 in Genome Data Viewer
    Location:
    7 B3; 7 29.07 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44640646..44647011, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44991222..44997638, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene protein arginine N-methyltransferase 1 Neighboring gene predicted gene 15545 Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene microRNA 7054

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulating Bcl2L12 expression in mast cells inhibits food allergy. Zheng PY, et al. Theranostics, 2019. PMID 31410196, Free PMC Article
    2. Bcl2-Like Protein 12 Is Required for the Aberrant T Helper-2 Polarization in the Heart by Enhancing Interleukin-4 Expression and Compromising Apoptotic Machinery in CD4+ T Cells. Chen X, et al. Circulation, 2018 Nov 27. PMID 30571346
    3. Bcl2-like protein 12 plays a critical role in development of airway allergy through inducing aberrant T(H)2 polarization. Liu ZQ, et al. J Allergy Clin Immunol, 2019 Jan. PMID 30227178
    4. Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils. Yang G, et al. Immunol Lett, 2020 Dec. PMID 33132183
    5. IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model. Walker WE, et al. J Leukoc Biol, 2012 Dec. PMID 23048204, Free PMC Article

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils.
      Title: Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils.
    2. Regulating Bcl2L12 expression in mast cells inhibits food allergy.
      Title: Regulating Bcl2L12 expression in mast cells inhibits food allergy.
    3. Bcl2-like protein 12 plays a critical role in development of airway allergy through inducing aberrant TH2 polarization.
      Title: Bcl2-like protein 12 plays a critical role in development of airway allergy through inducing aberrant T(H)2 polarization.
    4. Bcl2L12 plays a crucial role in the induction of Th2 polarization and allergic response in the intestine. The Bcl2L12 in CD4(+) T cells may be a potential target for the treatment of food allergy.
      Title: Bcl2L12 plays a critical role in the development of intestinal allergy.
    5. nuclear Bcl2L12 physically and functionally interacts with the p53 tumor suppressor
      Title: Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.
    6. Data show that apoptotic defect in Irf3(-/-)Bcl2l12(-/-) MEFs was rescued by the ectopic expression of Bcl2L12, but not IRF3.
      Title: Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bcl-2-like protein 12
    Names
    BCL2-like 12 (proline rich)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403495.1 → NP_001390424.1  bcl-2-like protein 12 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC155806

    2. NM_001403496.1 → NP_001390425.1  bcl-2-like protein 12 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC155806

    3. NM_001403497.1 → NP_001390426.1  bcl-2-like protein 12 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC155806
      UniProtKB/TrEMBL
      Q9D3J3

    4. NM_029410.4 → NP_083686.1  bcl-2-like protein 12 isoform b

      See identical proteins and their annotated locations for NP_083686.1

      Status: VALIDATED

      Source sequence(s)
      AC155806
      Consensus CDS
      CCDS21223.1
      UniProtKB/TrEMBL
      Q9D3J3
      Related
      ENSMUSP00000003290.5, ENSMUST00000003290.12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44640646..44647011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541267.5 → XP_006541330.1  bcl-2-like protein 12 isoform X3

      UniProtKB/TrEMBL
      A0A140LIT0
      Conserved Domains (1) summary
      PHA03132
      Location:4 → 158
      PHA03132; thymidine kinase; Provisional

    2. XM_036153537.1 → XP_036009430.1  bcl-2-like protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A140LIT0
      Related
      ENSMUSP00000146945.2, ENSMUST00000207443.2
      Conserved Domains (1) summary
      PHA03132
      Location:4 → 167
      PHA03132; thymidine kinase; Provisional

    RNA

    1. XR_003946575.2 RNA Sequence

      Related
      ENSMUST00000208128.2
    Nucleotide Protein Strain
    Heading Accession and Version

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