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    Carnmt1 carnosine N-methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67383, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Carnmt1provided by MGI
    Official Full Name
    carnosine N-methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1914633
    See related
    Ensembl:ENSMUSG00000024726 AllianceGenome:MGI:1914633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410127L17Rik
    Summary
    Predicted to enable carnosine N-methyltransferase activity and protein homodimerization activity. Predicted to be involved in carnosine metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and skeletal muscle. Orthologous to human CARNMT1 (carnosine N-methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 5.9), liver E14 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Carnmt1 in Genome Data Viewer
    Location:
    19 B; 19 13.18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (18648099..18684565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (18670759..18707201)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene osteoclast stimulating factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7637 Neighboring gene nicotinamide riboside kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9992 Neighboring gene RIKEN cDNA D030056L22 gene Neighboring gene STARR-seq mESC enhancer starr_45692 Neighboring gene STARR-positive B cell enhancer ABC_E3247 Neighboring gene predicted gene, 23238 Neighboring gene transient receptor potential cation channel, subfamily M, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism. Shimazu T, et al. Genes Dev, 2023 Aug 1. PMID 37612136, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism.
      Title: Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carnosine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnosine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carnosine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carnosine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carnosine N-methyltransferase
    Names
    UPF0586 protein C9orf41 homolog
    NP_001363980.1
    NP_001363981.1
    NP_001363982.1
    NP_001363983.1
    NP_001363984.1
    NP_080396.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377051.1 → NP_001363980.1  carnosine N-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:90 → 355
      N2227; N2227-like protein

    2. NM_001377052.1 → NP_001363981.1  carnosine N-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:83 → 348
      N2227; N2227-like protein

    3. NM_001377053.1 → NP_001363982.1  carnosine N-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:135 → 333
      N2227; N2227-like protein

    4. NM_001377054.1 → NP_001363983.1  carnosine N-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:90 → 288
      N2227; N2227-like protein

    5. NM_001377055.1 → NP_001363984.1  carnosine N-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:83 → 281
      N2227; N2227-like protein

    6. NM_026120.5 → NP_080396.2  carnosine N-methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_080396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC134906
      Consensus CDS
      CCDS29689.1
      UniProtKB/Swiss-Prot
      Q80UY1, Q9CWF3
      Related
      ENSMUSP00000025632.10, ENSMUST00000025632.11
      Conserved Domains (1) summary
      pfam07942
      Location:135 → 400
      N2227; N2227-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      18648099..18684565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940170.1 RNA Sequence

    2. XR_004940171.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UY1.1 GenPept UniProtKB/Swiss-Prot:Q80UY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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